壳核
纹状体
神经科学
丘脑
腹侧纹状体
心理学
基底神经节
癫痫
尾状核
默认模式网络
功能磁共振成像
多巴胺
中枢神经系统
作者
Tianyu Zhang,Yingying Zhang,Jiechuan Ren,Huanyu Zhou,Menghan Yang,Lei Li,Du Lei,Qiyong Gong,Dong Zhou,Tianhua Yang
标识
DOI:10.1016/j.yebeh.2023.109506
摘要
Purpose To explore the features of dynamic functional connectivity (dFC) variability of striatal-cortical/subcortical networks in juvenile absence epilepsy (JAE). Methods We collected resting-state functional magnetic imaging data from 18 JAE patients and 28 healthy controls. The striatum was divided into six pairs of regions: the inferior-ventral striatum (VSi), superior-ventral striatum (VSs), dorsal-caudal putamen, dorsal-rostral putamen, dorsal-caudate (DC) and ventral-rostral putamen. We assessed the dFC variability of each subdivision in the whole brain using the sliding-window method, and correlated altered circuit with clinical variables in JAE patients. Results We found altered dFC variability of striatal-cortical/subcortical networks in patients with JAE. The VSs exhibited decreased dFC variability with subcortical regions, and dFC variability between VSs and thalamus was negatively correlated with epilepsy duration. For the striatal-cortical networks, the dFC variability was decreased in VSi-affective network but increased in DC-executive network. The altered dynamics of striatal-cortical networks involved crucial nodes of the default mode network (DMN). Conclusion JAE patients exhibit excessive stability in the striatal-subcortical networks. For striatal-cortical networks in JAE, the striatal-affective circuit was more stable, while the striatal-executive circuit was more variable. Furthermore, crucial nodes of DMN were changed in striatal-cortical networks in JAE.
科研通智能强力驱动
Strongly Powered by AbleSci AI