阿霉素
体内
心脏毒性
化学
生物物理学
药物输送
药理学
癌细胞
癌症研究
癌症
医学
毒性
内科学
化疗
生物
有机化学
生物技术
作者
Peng Bai,Dan Li,Mingsong Shi,Jing Wang,Minghai Tang,Neng Qiu,Jiaolin Wen
标识
DOI:10.1016/j.jddst.2023.105030
摘要
Cardiotoxicity remains a challenge for the clinical application of doxorubicin. Here, a carrier-free self-assembled supramolecular named Doxorubicin-Rhein supramolecular (D-R Supra) was prepared by π-π stacking of Rhein and doxorubicin with green procedures. Molecular dynamics (MD) simulations showed that DOX molecules aggregated around Rhein molecules through intermolecular forces, resulting in a supramolecule with a particle size of about 200 nm and a DOX loading efficiency of 81.13 ± 4.70% and Rhein loading efficiency of up to 94.24 ± 3.28%. These supramolecules not only showed a sustained release effect compared with free drugs but also exhibited pH-dependent drug release profile. Notably, the blood circulation of DOX in this particle was significantly prolonged (>34 h) with 4.89 times that of free DOX, and the in vivo clearance rate was only one-third of that of free DOX. Tissue distribution experiments demonstrated that D-R Supra significantly reduced DOX distribution in heart tissue, and in vivo experiments demonstrated that D-R Supra significantly reduced inflammatory cell infiltration and connective tissue hyperplasia of heart tissue. In addition, the supramolecules can significantly inhibit tumor growth and prolong the survival time in comparison with free DOX in a highly malignant BL-2 secondary transplantation mouse model with clinical patient symptoms of Ph+ B-cell acute lymphoblastic leukemia (B-ALL). Therefore, the proposed excipient-free strategy has a significant effect of reducing the toxicity and increasing the efficiency of DOX and may be a promising delivery system for cancer therapy.
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