医学
咳嗽反射
慢性咳嗽
耐火材料(行星科学)
共济失调
哮喘
小脑共济失调
内科学
皮肤病科
反射
物理
精神科
天体生物学
作者
Barnaby Hirons,Riccardo Currò,Hisham Abubakar-Waziri,Katie Rhatigan,Bianca Rugginini,Joseph Shaw,Harini Kesavan,R. D. M. Hadden,Caroline Jolley,Jim H Hull,Peter Siu Pan Cho,Andrea Cortese,Surinder S. Birring
标识
DOI:10.1183/13993003.congress-2023.pa1912
摘要
Introduction: Chronic cough (CC) is often the presenting symptom of CANVAS; Cerebellar Ataxia, Neuropathy, and Vestibular Areflexia Syndrome, caused by biallelic repeat expansions in RFC1 gene. We investigated cough characteristics in CANVAS, compared to refractory chronic cough (RCC). Methods: Patients with neurologist-diagnosed CANVAS who had CC and patients with RCC without evidence of neuropathy were recruited. Symptoms were assessed with cough severity VAS, cough-specific Leicester Cough Questionnaire (LCQ) health status, and Cough Hypersensitivity Questionnaire (CHQ) for triggers. Objective 24hr cough frequency (CF) was measured with Leicester Cough Monitor and cough reflex sensitivity (CRS) with capsaicin challenge. Results: We recruited 53 patients with RCC and 8 patients with CANVAS. All patients with CANVAS had sensory neuropathy and abnormal nerve conduction studies, 7 had ataxia and vestibular areflexia. CC in CANVAS was refractory to asthma, reflux, or rhinitis treatments. Compared to RCC, patients with CANVAS had equal sex distribution and younger age of cough onset (median 33 vs 55 years), Table1. Patients with CANVAS had moderate-severe CF and QoL impact. CANVAS cough was associated with multiple triggers and heightened CRS, similar to RCC. Discussion: CC in CANVAS is refractory, impacts QoL, associated with cough reflex hypersensitivity, and presents at an earlier age compared to RCC. Studies to investigate the prevalence of CANVAS in patients with CC are needed.
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