Mendelian randomization to evaluate the causal relationship between liver enzymes and the risk of six specific bone and joint-related diseases

孟德尔随机化 医学 骨质疏松症 内科学 强直性脊柱炎 优势比 骨矿物 类风湿性关节炎 胃肠病学 基因型 生物 遗传学 基因 遗传变异
作者
Guiwu Huang,Wenchang Li,Yonglie Zhong,Wei‐Ming Liao,Zhiqi Zhang
出处
期刊:Frontiers in Immunology [Frontiers Media]
卷期号:14 被引量:4
标识
DOI:10.3389/fimmu.2023.1195553
摘要

Background Studies of liver dysfunction in relation to bone and joint-related diseases are scarce, and its causality remains unclear. Our objective was to investigate whether serum liver enzymes are causally associated with bone and joint-related diseases using Mendelian randomization (MR) designs. Methods Genetic data on serum liver enzymes (alkaline phosphatase (ALP); alanine transaminase (ALT); gamma-glutamyl transferase (GGT)) and six common bone and joint-related diseases (rheumatoid arthritis (RA), osteoporosis, osteoarthritis (OA), ankylosing spondylitis, psoriatic arthritis, and gout) were derived from independent genome-wide association studies of European ancestry. The inverse variance-weighted (IVW) method was applied for the main causal estimate. Complementary sensitivity analyses and reverse causal analyses were utilized to confirm the robustness of the results. Results Using the IVW method, the positive causality between ALP and the risk of osteoporosis diagnosed by bone mineral density (BMD) at different sites was indicated (femoral neck, lumbar spine, and total body BMD, odds ratio (OR) [95% CI], 0.40 [0.23–0.69], 0.35 [0.19–0.67], and 0.33 [0.22–0.51], respectively). ALP was also linked to a higher risk of RA (OR [95% CI], 6.26 [1.69–23.51]). Evidence of potential harmful effects of higher levels of ALT on the risk of hip and knee OA was acquired (OR [95% CI], 2.48 [1.39–4.41] and 3.07 [1.49–6.30], respectively). No causal relationship was observed between GGT and these bone and joint-related diseases. The study also found that BMD were all negatively linked to ALP levels (OR [95% CI] for TBMD, FN-BMD, and LS-BMD: 0.993 [0.991–0.995], 0.993 [0.988–0.998], and 0.993 [0.989, 0.998], respectively) in the reverse causal analysis. The results were replicated via sensitivity analysis in the validation process. Conclusions Our study revealed a significant association between liver function and bone and joint-related diseases.
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