A new benzophenone derivative from Aspergillus fumigatus WJ-131

AbstractA new benzophenone derivative, 8′-hydroxymonomethylsulochrin (1), together with eighteen known compounds (2-19) were produced by the endophytic fungus Aspergillus fumigatus WJ-131, isolated from the stem of Gardenia jasminoides. The structure of 1 was determined by extensive spectroscopic analysis and X-ray crystallography. Under the condition of concentration of 20.0 μM, the splenic lymphocytes proliferation rates of compounds 1 and 7 induced by LPS were 39.4% and 38.1% (LPS, the splenic lymphocytes cell proliferation rates of 21.3%), and the splenic lymphocytes proliferation rate of compounds 7 induced by ConA is 44.6% (ConA, the splenic lymphocytes proliferation rates of 28.9%). Therefore, compounds 1 and 7 promoted the proliferation of ConA/LPS-stimulated splenic lymphocytes at 20.0 μM in vitro. In addition, compound 1 showed weak antibacterial activity against Fusarium oxysporum.Keywords: Aspergillus fumigatusbenzophenone derivativeimmunoregulatory activityGardenia jasminoides AcknowledgmentsThe authors would like to thank Advanced Analysis and Measurement Center of Yunnan University for the sample testing service.Disclosure statementNo potential conflict of interest was reported by the authors.Additional informationFundingThis work was supported by the Natural Science Foundation of China (No. 82160799); the Program for Innovative Research Team of Yunnan Province (202105AE160006); the Project of Yunnan Characteristic Plant Screening and R&D Service CXO Platform (2022YKZY001); Yunnan University′s Research Innovation Fund for Graduate Students (No. 2021T056); the Innovation and Entrepreneurship Training Program for college students of Yunnan University (202205120). Yunnan Key Laboratory of Pharmacology for Natural Products open fund project (YKLP NP-G2405).