自噬
坐骨神经
背根神经节
移植
内吞作用
神经损伤
粒体自噬
细胞生物学
医学
病理
男科
化学
生物
解剖
细胞凋亡
内科学
外科
背
受体
生物化学
作者
LI Dong-dong,Haolin Liu,Chaochao Li,Yanjun Guan,Xing Xiong,Ruichao He,Zhibo Jia,Lijing Liang,Jinjuan Zhao,Xinyu Miao,Li Wang,Jiang Peng
标识
DOI:10.1177/09636897241291278
摘要
Autologous nerve transplantation (ANT) remains the gold standard for treating nerve defects. However, its efficacy in nerve repair still requires improvement. Mitochondrial dysfunction resulting from nerve injury may be a significant factor limiting nerve function restoration. This study investigated the impact of supplementing exogenous mitochondria (EM) in ANT and explored its effect on the efficacy of ANT in nerve repair. SD rats were used to prepare a model of a 10 mm sciatic nerve defect repaired by ANT (Auto group) and a model of ANT supplemented with EM (Mito group). At 12 weeks post-operation, functional, neurophysiological, and histological evaluations of the target organ revealed that the Mito group exhibited significantly better outcomes compared with the Auto group, with statistically significant differences (
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