作者
Shadi A. Esfahani,Hua Ma,Shriya Krishna,Sergey Shuvaev,Mark F Sabbagh,Caitlin Deffler,Nicholas J. Rotile,Jonah Weigand‐Whittier,Iris Y. Zhou,Ciprian Catana,Onofrio A. Catalano,David T. Ting,Pedram Heidari,Eric Abston,Michael Lanuti,Genevieve M. Boland,Priyanka Pathak,Hannah Roberts,Kenneth K. Tanabe,Motaz Qadan,Carlos Fernández-del Castillo,Angela R. Shih,Aparna R. Parikh,Colin D. Weekes,Theodore S. Hong,Peter Caravan
摘要
Pancreatic ductal adenocarcinoma (PDAC) is an invasive and rapidly progressive malignancy. A major challenge in patient management is the lack of a reliable imaging tool to monitor tumor response to treatment. Tumor-associated fibrosis characterized by high type I collagen is a hallmark of PDAC, and fibrosis further increases in response to neoadjuvant chemoradiotherapy (CRT). We hypothesized that molecular positron emission tomography (PET) using a type I collagen-specific imaging probe,