Near‐Infrared Carbon Dots With Antibacterial and Osteogenic Activities for Sonodynamic Therapy of Infected Bone Defects

脚手架 材料科学 声动力疗法 生物医学工程 骨愈合 自愈水凝胶 体内 抗菌活性 纳米技术 化学 医学 细菌 外科 生物化学 遗传学 生物技术 活性氧 高分子化学 生物
作者
Jianfei Tang,Jinyan Hu,Xue Bai,Yang Wang,Jinming Cai,Zhenlin Zhang,Bijiang Geng,Dengyu Pan,Longxiang Shen
出处
期刊:Small [Wiley]
标识
DOI:10.1002/smll.202404900
摘要

Abstract Repairing infected bone defects is hindered by the presence of stubborn bacterial infections and inadequate osteogenic activity. The incorporation of harmful antibiotics not only fosters the emergence of multidrug‐resistant bacteria, but also diminishes the osteogenic properties of scaffold materials. In addition, it is essential to continuously monitor the degradation kinetics of scaffold materials at bone defect sites, yet the majority of bone repair materials lack imaging capability. To address these issues, this study reports for the first time the development of a single nanomaterial with triple functionality: efficient sonodynamic antibacterial activity, accelerated bone defect repair capability, and NIR imaging ability for visualized therapy of infected bone defects. Through rationally regulating the surface functional groups, the obtained multifunctional NIR carbon dots (NIR‐CD) exhibit p–n junction‐enhanced sonodynamic activity, narrow bandgap‐facilitated NIR imaging capability, and negative charge‐augmented osteogenic activity. The validation of NIR‐CDs antibacterial and osteogenic activities in vivo is conducted by constructing 3D injectable hydrogels encapsulated by NIR‐CDs (NIR‐CD/GelMA). The implantation of multifunctional NIR‐CD/GelMA hydrogel scaffolds in a model of MRSA‐infected craniotomy defects results in almost complete restoration of the infected bone defects after 60 days. These findings will provide traceable, renewable, repairable and antibacterial candidate biomaterials for bone tissue engineering.
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