体外
钙
计算机科学
细胞生物学
生物医学工程
生化工程
材料科学
化学
生物
生物化学
工程类
冶金
作者
Ashish Pandit,Abhishek Indurkar,Jānis Ločs,Håvard J. Haugen,Dagnija Loča
标识
DOI:10.1002/adhm.202401307
摘要
Abstract The replication of bone physiology under laboratory conditions is a prime target behind the development of in vitro bone models. The model should be robust enough to elicit an unbiased response when stimulated experimentally, giving reproducible outcomes. In vitro bone tissue generation majorly requires the availability of cellular components, the presence of factors promoting cellular proliferation and differentiation, efficient nutrient supply, and a supporting matrix for the cells to anchor – gaining predefined topology. Calcium phosphates (CaP) are difficult to ignore while considering the above requirements of a bone model. Therefore, the current review focuses on the role of CaP in developing an in vitro bone model addressing the prerequisites of bone tissue generation. Special emphasis is given to the physico‐chemical properties of CaP that promote osteogenesis, angiogenesis and provide sufficient mechanical strength for load‐bearing applications. Finally, the future course of action is discussed to ensure efficient utilization of CaP in the in vitro bone model development field.
科研通智能强力驱动
Strongly Powered by AbleSci AI