Cluster analysis of 100 Marfan patients based on aortic 4D flow MRI and Z-score: insights into disease heterogeneity and stratification of subgroups

医学 神经组阅片室 介入放射学 马凡氏综合征 危险分层 内科学 放射科 疾病 超声波 心脏病学 神经学 精神科
作者
Alexander Lenz,F. Bahr,Christoph Riedel,Felicia Wright,M Sinn,Shuo Zhang,Marion Schuett,Lennart Well,Gerhard Adam,Yskert Von Kodolitsch,Bjoern P. Schoennagel,Peter Bannas
出处
期刊:European Radiology [Springer Science+Business Media]
标识
DOI:10.1007/s00330-024-11034-6
摘要

Abstract Objectives 4D flow MRI-derived variables from Marfan patients are highly heterogeneous. Our aim was to identify distinct Marfan patient subgroups based on aortic 4D flow MRI and Z-score for stratification of distinct hemodynamic profiles and clinical features by means of hierarchical cluster analysis. Materials and methods One hundred Marfan patients underwent baseline aortic 4D flow MRI at 3 T. Z-scores, degree of helical and vortical flow, wall shear stress, flow displacement, and peak velocity were determined in the ascending aorta. Sex, age, BMI, antihypertensive medication, and dural ectasia were recorded. Hierarchical cluster analysis was performed using 4D flow MRI variables and Z-scores as input. Results Cluster analysis resulted in three distinct clusters characterized by different Z-scores (mean ± SD); cluster 1: 0.4 ± 1.1 vs. cluster 2: 3.1 ± 1.1 vs. cluster 3: 3.6 ± 1.9. The three clusters delivered differences in helical and vortical flow patterns (global p = 0.003 and p < 0.001, respectively), wall shear stress (0.49 ± 0.11 vs. 0.44 ± 0.12 vs. 0.37 ± 0.09 N/m 2 , global p < 0.001), flow displacement (0.11 ± 0.05 vs. 0.16 ± 0.08 vs. 0.15 ± 0.07, global p = 0.006), and peak velocity (76.3 ± 9.0 vs. 60.1 ± 7.3 vs. 56.0 ± 7.8 cm/s, global p < 0.001). Patients in cluster 1 and 2 were relevantly younger than in cluster 3 (32.3 ± 13.8 vs. 32.8 ± 12.6 vs. 40.2 ± 15.0 years, all pairwise ∆ p < 0.0297). Conclusion Hierarchical cluster analysis based on aortic 4D flow MRI and Z-score revealed three distinct subgroups of Marfan patients, each characterized by specific hemodynamic profiles and clinical features. Follow-up of our patients is warranted to assess if 4D flow MRI- and Z-score-based stratification can predict future aortic diameter growth and ultimately improve outcomes. Clinical relevance statement A combination of Z-score and 4D flow MRI-derived parameters may help identify subgroups of Marfan patients representing different stages or phenotypes of aortic disease, which require specific management strategies. Key Points Four-dimensional (4D) flow MRI-derived variables of Marfan patients are highly heterogeneous across varying Z-scores . Cluster analysis based on 4D flow MRI and Z-score revealed three distinct subgroups of Marfan patients . A combination of Z-score and 4D flow MRI-derived parameters may identify different stages of aortic disease in Marfan patients . Graphical Abstract
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
zzz完成签到,获得积分10
1秒前
咚咚咚完成签到,获得积分10
2秒前
隐形曼青应助青青子衿采纳,获得10
2秒前
今后应助潇湘雪月采纳,获得10
3秒前
NexusExplorer应助crazy采纳,获得10
3秒前
Ava应助超帅青烟采纳,获得10
3秒前
Luffa完成签到,获得积分10
4秒前
moxi摩西发布了新的文献求助10
5秒前
7秒前
追寻电脑发布了新的文献求助10
7秒前
佳佳佳发布了新的文献求助30
10秒前
脑洞疼应助袁超采纳,获得30
11秒前
潇洒的白凝完成签到,获得积分10
15秒前
123完成签到,获得积分10
16秒前
16秒前
qphys完成签到,获得积分10
17秒前
hyf发布了新的文献求助10
17秒前
mjf111完成签到,获得积分10
20秒前
21秒前
wsj发布了新的文献求助10
21秒前
烟酒不离生完成签到,获得积分10
22秒前
23秒前
Jasper应助xyj6486采纳,获得10
24秒前
24秒前
26秒前
于平川春野完成签到 ,获得积分10
26秒前
汉堡包应助我不吃胡萝卜采纳,获得10
28秒前
28秒前
英姑应助潇湘雪月采纳,获得10
28秒前
Xw发布了新的文献求助10
28秒前
29秒前
种花家的狗狗完成签到,获得积分10
29秒前
wanci应助wsj采纳,获得10
31秒前
李昕123完成签到 ,获得积分10
32秒前
超帅青烟发布了新的文献求助10
32秒前
友好的睫毛完成签到 ,获得积分10
32秒前
量子星尘发布了新的文献求助10
34秒前
木皆完成签到,获得积分10
36秒前
38秒前
ChatGPT发布了新的文献求助10
39秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989390
求助须知:如何正确求助?哪些是违规求助? 3531487
关于积分的说明 11254109
捐赠科研通 3270153
什么是DOI,文献DOI怎么找? 1804887
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809174