表观遗传学
衰老
细胞衰老
表达式(计算机科学)
生物
计算生物学
神经科学
进化生物学
细胞生物学
计算机科学
遗传学
表型
基因
程序设计语言
作者
Nirmalya Dasgupta,Rouven Arnold,Anaïs Equey,Armin Gandhi,Peter D. Adams
标识
DOI:10.1038/s41514-024-00172-2
摘要
Senescence and epigenetic alterations stand out as two well-characterized hallmarks of aging. When cells become senescent, they cease proliferation and release inflammatory molecules collectively termed the Senescence-Associated Secretory Phenotype (SASP). Senescence and SASP are implicated in numerous age-related diseases. Senescent cell nuclei undergo epigenetic reprogramming, which intricately regulates SASP expression. This review outlines the current understanding of how senescent cells undergo epigenetic changes and how these alterations govern SASP expression.
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