前列腺癌
谷氨酸羧肽酶Ⅱ
癌症
前列腺
癌症研究
医学
内科学
作者
Se-Han Kim,Jeonghyeon Lee,Jaesung Park
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2024-09-24
标识
DOI:10.1021/acsabm.4c01045
摘要
Extracellular vesicles are ideal therapeutic potentiators for various diseases. However, they commonly lack targeting capability and are rapidly cleared by phagocytes. This requires appropriate administration at high doses, which can lead to toxic and adverse reactions. To overcome these limitations, we developed bleb nanovesicles containing human Fcγ receptor I (hCD64), known for their strong affinity to monomeric IgG. In this study, we focused on prostate cancer, which has a specific membrane antigen. We have utilized the hCD64-expressing bleb nanovesicles attaching anti-prostate-specific membrane antigen (PSMA) antibodies and confirmed their targeting ability in PSMA-related cell lines and prostate cancer xenograft models. Our findings underscore the promising potential of nanovesicle Fcγ receptor-IgG as a platform for cancer diagnosis and therapy systems, inspiring further research.
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