富维斯特朗
医学
内科学
肿瘤科
乳腺癌
激素受体
激素
内分泌系统
癌症
癌症研究
内分泌学
雌激素受体
作者
Nicholas C. Turner,Mafalda Oliveira,Sacha J. Howell,Florence Dalenc,Javier Cortés,Henry Gómez,Xichun Hu,Komal Jhaveri,Petr Krivorotko,Sibylle Loibl,Serafín Morales,Meena Okera,Yeon Hee Park,Joohyuk Sohn,Masakazu Toi,Eriko Tokunaga,Samih Yousef,Lyudmila Zhukova,Elza C. de Bruin,Lynda Grinsted,Gaia Schiavon,Andrew Foxley,Hope S. Rugo
标识
DOI：10.1056/nejmoa2214131
摘要
AKT pathway activation is implicated in endocrine-therapy resistance. Data on the efficacy and safety of the AKT inhibitor capivasertib, as an addition to fulvestrant therapy, in patients with hormone receptor-positive advanced breast cancer are limited.
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