细胞生物学
细胞外
脱颗粒
中性粒细胞胞外陷阱
炎症
生物
免疫学
免疫系统
分泌物
颗粒(地质)
过敏性炎症
细胞溶解
遗传学
体外
生物化学
细胞毒性
古生物学
受体
作者
Glaucia A. Thompson‐Souza,Claudia Regina Isaías Vasconcelos,Josiane S. Neves
出处
期刊:Life Sciences
[Elsevier]
日期:2022-11-12
卷期号:311: 121191-121191
被引量:7
标识
DOI:10.1016/j.lfs.2022.121191
摘要
Eosinophils are multitasking granulocytes with implications for allergies, host response to helminths and, more recently, described roles in immunomodulation, homeostasis and tissue remodeling. Eosinophils secrete their preformed granule proteins by different pathways, especially piecemeal degranulation and cytolysis with granule release. Currently, there are different insights related to eosinophils' functional roles and biology that deserve to be highlighted. Cytolysis with granule release has also been associated with DNA extracellular trap formation, one of the most intriguing, recently described mechanisms of leukocyte activation. Focusing on DNA extracellular trap release, there are lessons to be learned from neutrophils considering the multitasking roles of these structures in inflammation, and the mechanisms involved in their release. This review explores a comparative analysis of the current knowledge considering DNA traps extrusion in neutrophils and eosinophils and update the major findings regarding the presence of these entities in eosinophilic-associated immune responses, inflammation and diseases.
科研通智能强力驱动
Strongly Powered by AbleSci AI