表观遗传学
疾病
组蛋白
计算生物学
生物
DNA甲基化
后生
生物信息学
表观遗传学
组学
医学
基因表达
基因
遗传学
病理
作者
Miron Sopić,Emma Robinson,Costanza Emanueli,Prashant K. Srivastava,Claudio Angione,Carlo Gaetano,Gianluigi Condorelli,Fabio Martelli,Thierry Pedrazzini,Yvan Devaux
标识
DOI:10.1007/s00395-023-00986-3
摘要
Abstract The number of “omics” approaches is continuously growing. Among others, epigenetics has appeared as an attractive area of investigation by the cardiovascular research community, notably considering its association with disease development. Complex diseases such as cardiovascular diseases have to be tackled using methods integrating different omics levels, so called “multi-omics” approaches. These approaches combine and co-analyze different levels of disease regulation. In this review, we present and discuss the role of epigenetic mechanisms in regulating gene expression and provide an integrated view of how these mechanisms are interlinked and regulate the development of cardiac disease, with a particular attention to heart failure. We focus on DNA, histone, and RNA modifications, and discuss the current methods and tools used for data integration and analysis. Enhancing the knowledge of these regulatory mechanisms may lead to novel therapeutic approaches and biomarkers for precision healthcare and improved clinical outcomes.
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