生物标志物
生物标志物发现
疾病
医学
药物开发
药物发现
药学
药品
计算生物学
生物信息学
药理学
内科学
蛋白质组学
生物
生物化学
基因
作者
Kenta Noda,Yeongjoo Lim,Shintaro Sengoku,Kota Kodama
标识
DOI:10.1016/j.drudis.2023.103677
摘要
Alzheimer’s disease (AD) has no effective treatment, although antibody drugs targeting beta-amyloid, mainly aducanumab, have produced useful clinical results. Biomarkers can be used to determine drug regimens effectively and to monitor the effects of drugs. A concept in which biomarkers reflect disease states is emerging. Although several AD biomarker studies have been reported, measurement methods and target molecules are still being validated, and various biomarkers are being explored. This study analyzed trends in research on AD biomarkers using bibliometric methods, revealing an exponential increase in research reports in this field, with the US most active in research. Analysis of the ‘Burst’ biomarkers using CiteSpace revealed that networks centered on authors, rather than networks among countries, drive new research trends in this area.
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