医学
磁共振成像
唾液学
痹症科
病态的
腮腺
放射科
核医学
内科学
病理
作者
Yujun Rao,Nan Xu,Yongbin Zhang,Yuxuan Fang,Longlong Tian,Xingxing Min,Chen Guiyu,Tiantian Dai,Nianxing Liu,Xuanhan Wang,Xiuting Gu,Hanpeng Lai,Wei Wang,Guoqing Li
标识
DOI:10.1111/1756-185x.14528
摘要
Abstract Aim To evaluate the utility of magnetic resonance imaging (MRI) and magnetic resonance sialography (MRS) for diagnosis of primary Sjögren syndrome (pSS) singly or integrated with 2016 American College of Rheumatology (ACR)/European League Against Rheumatic Diseases (EULAR) classification criteria. Methods The diagnostic efficiencies of MRI, MRS, and labial salivary gland biopsy (LSGB) were evaluated. The prediction model was established by multivariate analysis. Finally, performance of the ACR/EULAR criteria was evaluated after addition of MRI + MRS or replacement of original items by MRI + MRS. Results The combined use of LSGB + MRI + MRS provided the greatest diagnostic value. MRI and MRS grade had positive correlations with disease duration and pathological grade of the labial gland (both P < 0.001). MRI and MRS grade had positive correlations with xerostomia severity and negative correlations with unstimulated salivary flow rate (both P < 0.001). The consistency of MRI grade and MRS grade in the diagnosis of parotid gland lesions was poor (κ = 0.253, P < 0.001). The diagnostic efficiency of our prediction model (AUC 0.906) was similar to that of criteria from the ACR/EULAR (AUC 0.930). Adding MRI + MRS to the ACR/EULAR criteria improved the sensitivity (92.3% vs 90.8%), whereas the specificity remained the same (88.9% vs 89.1%). Replacing LSGB by MRI + MRS in the ACR/EULAR criteria decreased both sensitivity and specificity (88.1% vs 90.8% and 86.4% vs 89.1%, respectively). Conclusion The combined application of MRI and MRS has ideal clinical application value in the diagnosis of early‐stage pSS. Validity of the ACR/EULAR criteria remains high after incorporation of MRI + MRS.
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