化学
催化作用
羟基化
药物化学
组合化学
有机化学
酶
作者
Juting Liao,Ruirui Zhai,Xiaoyang Gao,Hongliang Wu,Dulin Kong,Shuojin Wang,Xun Chen
标识
DOI:10.1002/adsc.202401220
摘要
Abstract An efficient Rh(III)‐catalyzed C−H bond activation/cyclization of 2‐arylbenzimidazoles with CF 3 ‐imidoyl sulfoxonium ylides has been achieved, yielding diverse CF 3 − and amino‐disubstituted 5,6‐dihydrobenzoimidazo[2,1‐ a ]isoquinolines, which could undergo a deaminative hydroxylation to access CF 3 − and hydroxy‐disubstituted 5,6‐dihydrobenzoimidazo[2,1‐ a ]isoquinolines catalyzed by Sc(OTf) 3 . This developed strategy features easily available starting materials, broad substrate scope, good scalability and high efficiency. Moreover, the antitumor activities of selected products against some human cancer cell lines were also investigated, and the results indicated that several products show antiproliferative activities.
科研通智能强力驱动
Strongly Powered by AbleSci AI