Gray matter reserve modulates the association between glymphatic system function and cognition in patients with T2DM

认知 基于体素的形态计量学 内科学 萎缩 人口 生物标志物 医学 线性回归 心理学 白质 磁共振成像 精神科 统计 化学 放射科 环境卫生 生物化学 数学
作者
Wenqing Xia,Xiao Yin,Yujie Zhang,Shenghui Ge,Yuchen Chen,Jianhua Ma
出处
期刊:Neuroendocrinology [Karger Publishers]
卷期号:: 1-18
标识
DOI:10.1159/000542902
摘要

Introduction: We aims to explore the relationship between the glymphatic function and cognitive function in patients with T2DM and whether this relationship is modulated by gray matter (GM) integrity. Methods: In total, 65 patients with T2DM and 65 healthy controls (HCs) were recruited. All participants underwent evaluation using a comprehensive cognitive assessment scale. The ALPS index was calculated based on DTI data, and the disparity in ALPS index values between groups was examined. The voxel-based morphometry method was used to perform GM volume analysis. Multiple linear regression analysis was conducted to identify the GM regions associated with the ALPS index. The interactions among the ALPS index, GM volume and cognition were explored. Results: The ALPS index in patients with T2DM was significantly lower than that in HCs. In addition, our analysis revealed a correlation between the ALPS index and GM volume in the insular region, and this region was consistent with the GM atrophy region observed in the patient cohort. Moreover, a significant negative correlation was observed between the ALPS index in patients and performance on the Trail Making Test Part-A, and this relationship was moderated by GM integrity. Conclusion: A decreased ALPS index was found in T2DM patients, indicating impaired glymphatic function in this population. Furthermore, the association between the ALPS index and cognitive performance in T2DM patients was influenced by GMV in insula. Therefore, the ALPS index has the potential to be used as a biomarker of cognitive impairment in diabetic patients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
ziying126发布了新的文献求助10
5秒前
登徒子好色完成签到,获得积分10
6秒前
8秒前
科研通AI5应助zcydbttj2011采纳,获得10
8秒前
石一完成签到 ,获得积分10
9秒前
华仔应助芝麻采纳,获得10
11秒前
13秒前
DT驳回了传奇3应助
15秒前
16秒前
Celestine完成签到,获得积分10
17秒前
Cyrus完成签到 ,获得积分10
18秒前
18秒前
七只狐狸发布了新的文献求助10
20秒前
火花完成签到 ,获得积分10
21秒前
muomuo完成签到,获得积分10
21秒前
24秒前
24秒前
24秒前
搁浅完成签到,获得积分10
25秒前
cyh时代完成签到 ,获得积分10
29秒前
科研小白发布了新的文献求助10
29秒前
31秒前
32秒前
32秒前
乐乐应助Venus采纳,获得10
34秒前
科研通AI5应助wshengnan采纳,获得10
34秒前
Biye应助hachii采纳,获得10
34秒前
Flori发布了新的文献求助30
35秒前
38秒前
苏东方完成签到,获得积分10
38秒前
岳莹晓完成签到 ,获得积分10
38秒前
Skywalker完成签到,获得积分10
38秒前
SWL完成签到,获得积分10
39秒前
苏桑焉完成签到 ,获得积分10
39秒前
真神阿佳完成签到 ,获得积分10
39秒前
Akim应助科研小白采纳,获得10
39秒前
41秒前
赘婿应助qiu采纳,获得10
41秒前
41完成签到,获得积分10
43秒前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2700
Neuromuscular and Electrodiagnostic Medicine Board Review 1000
こんなに痛いのにどうして「なんでもない」と医者にいわれてしまうのでしょうか 510
The First Nuclear Era: The Life and Times of a Technological Fixer 500
ALUMINUM STANDARDS AND DATA 500
Walter Gilbert: Selected Works 500
岡本唐貴自伝的回想画集 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3667802
求助须知:如何正确求助?哪些是违规求助? 3226272
关于积分的说明 9768903
捐赠科研通 2936222
什么是DOI,文献DOI怎么找? 1608316
邀请新用户注册赠送积分活动 759622
科研通“疑难数据库(出版商)”最低求助积分说明 735407