已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Thermal Ablation for Papillary Thyroid Carcinoma

乳头状癌 热烧蚀 烧蚀 甲状腺 医学 甲状腺癌 放射科 普通外科 内科学
作者
Lin Yan,Yingying Li,Xinyang Li,Jing Xiao,Haoyu Jing,Zhen Yang,Miao Li,Qing Song,Shu‐Rong Wang,Ying Che,Yukun Luo
出处
期刊:JAMA otolaryngology-- head & neck surgery [American Medical Association]
标识
DOI:10.1001/jamaoto.2024.3229
摘要

Importance Image-guided thermal ablation has been administered for patients with T1N0M0 papillary thyroid carcinoma (PTC) who elect to not undergo surgery or receive active surveillance. Considering the indolent nature of PTC, long-term outcomes of ablation are needed. Objective To investigate l0-year outcomes of thermal ablation in treating T1N0M0 PTC. Design, Setting, and Participants This multicenter study was conducted at 4 university-affiliated hospitals in China and included 179 consecutive patients with T1N0M0 PTC (median [IQR] volume, 88.0 [163.2] mm 3 ) who underwent thermal ablation between June 2010 and March 2014. Patients who were ineligible to undergo surgery or elected not to were included, and patients had PTC tumors that were smaller than 20 mm as confirmed by biopsy; no clinical or imaging evidence of extrathyroidal extension, lymph node metastasis (LNM), or distant metastasis; and no history of neck irradiation. Main Outcomes and Measures The primary outcomes were disease progression (LNM, newly developed tumors, persistent tumors, and distant metastasis) and disease-free survival (DFS). Secondary outcomes were technical success, volume reduction rate, tumor disappearance, complications, and delayed surgery. DFS was calculated using a Kaplan-Meier analysis. Results Among the 179 patients, the mean (SD) age was 45.8 (12.7) years, and 118 (65.9%) were female. During a mean (SD) follow-up period of 120.8 (10.8) months, disease progression was found in 11 of 179 patients (6.1%), including LNM in 4 patients (2.2%), newly developed tumors in 6 patients (3.3%), and persistent tumor in 1 patient (0.6%). The 10-year DFS was 93.9%. The technical success, median volume reduction rate, and tumor disappearance rate was 100%, 100%, and 97.2%, respectively. The magnitude of the disease progression (6.1% vs 7.1%; difference, 1.0%; 95% CI, −6.5% to 25.6%) and DFS (93.9% vs 92.9%; difference, 1.0%, 95% CI, −6.5% to 25.6%) between patients with T1a and T1b tumors was small. The difference in the rate of tumor disappearance between T1a and T1b tumors was large (99.4% vs 71.4%; difference, 28.0%; 95% CI, 10.9%-54.0%). One patient experienced transient voice hoarseness (0.6%). Because of anxiety, 1 patient underwent delayed surgery (0.6%). Conclusions and Relevance The results of this 10-year multicenter cohort study suggest that thermal ablation is an effective and safe alternative for patients with T1N0M0 PTC who do not undergo surgery or receive active surveillance. For safe and effective treatment, accurate radiologic evaluation, an understanding of ablation techniques, and experienced physicians are recommended.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
核桃小丸子完成签到 ,获得积分10
1秒前
5秒前
坦率完成签到,获得积分10
5秒前
7秒前
Hello应助不一样是怎样采纳,获得10
7秒前
欣欣完成签到,获得积分20
8秒前
科研通AI2S应助执着千筹采纳,获得10
8秒前
wxwxwx77完成签到,获得积分10
8秒前
栗子完成签到 ,获得积分10
8秒前
8秒前
9秒前
10秒前
Sunny发布了新的文献求助10
11秒前
Jenny发布了新的文献求助10
15秒前
shenhai完成签到,获得积分10
16秒前
zzzyyy应助乐乐采纳,获得10
20秒前
23秒前
24秒前
FashionBoy应助科研通管家采纳,获得10
25秒前
25秒前
科研通AI2S应助科研通管家采纳,获得10
25秒前
领导范儿应助科研通管家采纳,获得10
25秒前
小二郎应助科研通管家采纳,获得100
25秒前
番茄鱼完成签到 ,获得积分10
25秒前
香菜小土狗完成签到 ,获得积分10
25秒前
烟花应助Jenny采纳,获得10
27秒前
如意完成签到,获得积分10
28秒前
5年科研3年毕业完成签到,获得积分10
29秒前
zzzyyy应助自然垣采纳,获得10
29秒前
29秒前
积极的夏天完成签到 ,获得积分10
35秒前
小王同学完成签到,获得积分10
36秒前
自由冰凡完成签到 ,获得积分10
36秒前
WRX完成签到,获得积分10
38秒前
浮云完成签到,获得积分10
38秒前
不安的靖完成签到,获得积分10
40秒前
康康完成签到 ,获得积分10
40秒前
丘比特应助WRX采纳,获得30
42秒前
小星星完成签到,获得积分10
43秒前
开心幻悲完成签到 ,获得积分10
44秒前
高分求助中
Sustainability in Tides Chemistry 2800
The Young builders of New china : the visit of the delegation of the WFDY to the Chinese People's Republic 1000
Rechtsphilosophie 1000
Bayesian Models of Cognition:Reverse Engineering the Mind 888
Le dégorgement réflexe des Acridiens 800
Defense against predation 800
Very-high-order BVD Schemes Using β-variable THINC Method 568
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3136953
求助须知:如何正确求助?哪些是违规求助? 2787893
关于积分的说明 7783824
捐赠科研通 2443962
什么是DOI,文献DOI怎么找? 1299536
科研通“疑难数据库(出版商)”最低求助积分说明 625464
版权声明 600954