丝素
类有机物
自愈水凝胶
软骨
骨关节炎
化学
生物医学工程
丝绸
解剖
医学
细胞生物学
病理
材料科学
生物
高分子化学
复合材料
替代医学
作者
Congyi Shen,Ziyang Zhou,Ruiyang Li,Siyoung Yang,Dongyang Zhou,Fengjin Zhou,Zhen Geng,Jiacan Su
出处
期刊:Theranostics
[Ivyspring International Publisher]
日期:2024-12-02
卷期号:15 (2): 560-584
被引量:6
摘要
Osteoarthritis (OA) is a common joint disease characterized by cartilage degeneration. It can cause severe pain, deformity and even amputation risk. However, existing clinical treatment methods for cartilage repair present certain deficiencies. Meanwhile, the repair effect of cartilage tissue engineering is also unsatisfactory. Cartilage organoids are multicellular aggregates with cartilage-like three-dimensional structure and function. On the one hand, cartilage organoids can be used to explore the pathogenesis of OA by constructing disease models. On the other hand, it can be used as filler for rapid cartilage repair. Extracellular matrix (ECM)-like three-dimensional environment is the key to construct cartilage organoids. Silk fibroin (SF)-based hydrogels not only have ECM-like structure, but also have unique mechanical properties and remarkable biocompatibility. Therefore, SF-based hydrogels are considered as ideal biomaterials for constructing cartilage organoids. In this review, we reviewed the studies of cartilage organoids and SF-based hydrogels. The advantages of SF-based hydrogels in constructing cartilage organoids and the iterative optimization of cartilage organoids through designing hydrogels by using artificial intelligence (AI) calculation are also discussed. This review aims to provide a theoretical basis for the treatment of OA using SF-based biomaterials and cartilage organoids.
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