Type-2 diabetes mellitus-associated cancer risk: In pursuit of understanding the possible link

胰岛素抵抗 2型糖尿病 医学 叙述性评论 评论文章 生物信息学 癌症 2型糖尿病 胰岛素 糖尿病 内科学 生物 内分泌学 重症监护医学 病理
作者
Srinivasa Rao Vulichi,Ashish Runthala,Nagaraju Begari,Kumar Rupak,Venkata Rao Chunduri,Suman Kapur,Appa Rao Chippada,Durga Srinivasa Murthy Sistla
标识
DOI:10.1016/j.dsx.2022.102591
摘要

The insulin resistance-mediated abnormal gluconeogenesis when exceeds a given threshold culminates in type 2 diabetes mellitus (T2DM). This induces severe cellular oxidative stress that may eventually facilitate typical neoplastic transformations. This narrative review aims to portray some of the plausible key mechanistic links bridging T2DM and specific cancers.A thorough literature search was conducted in the PubMedCentral database to retrieve information from various reputed biomedical reports/articles published from the year 2000. The information regarding the key biochemical signaling pathways mediating the carcinogenic transformation, especially in T2DM patients, was extensively excavated to systematically compile and present a narrative review.T2DM-associated insulin resistance is known to negatively influence certain crucial genetic and metabolic components (such as insulin/IGFs, PI-3K/Akt, AMPK, and AGEs/RAGE) that may eventually lead to neoplastic transformation. In particular, the risk of developing cancers like pancreatic, colorectal, breast, liver, endometrial, and bladder seems to be more significant in T2DM patients.Despite the fact that several studies have suggested a possible correlation between T2DM and cancer mortality, a more detailed research at both pre-clinical and clinical levels is still required so as to fully understand the intricate relationship and make a precise conclusion.
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