Front Cover: Physiologically‐Based Kinetic Modeling Predicts Similar In Vivo Relative Potency of Senecionine N‐Oxide for Rat and Human at Realistic Low Exposure Levels

Mol. Nutr. Food Res. 2023, 67, 202200293 DOI: 10.1002/mnfr.202200293 Pyrrolizidine alkaloid N-oxide (PANO), a common plant-based food protoxin, can be reduced to pyrrolizidine alkaloid (PA) by liver S9 and gut microbiota, causing liver toxicity and carcinogenicity. In article number 2200293, Frances Widjaja and co-workers used new approach methodologies to predict the relative potency (REP) of PANO to PA in both rats and humans at low and high dose levels.