糖尿病肾病
医学
炎症
钨酸钠
纤维化
钨酸盐
内科学
泌尿科
肾
化学
钨
有机化学
作者
Alejandro J. Yáñez,Karen Jaramillo,Pamela Silva,Mariana Yáñez A,Moises Sandoval,Daniel Carpio,Marcelo Aguilar
标识
DOI:10.1016/j.amjms.2024.06.001
摘要
Diabetic Nephropathy is one of the most severe complications of Diabetes Mellitus and the main cause of end-stage kidney disease worldwide. Despite the therapies available to control blood glucose and blood pressure, many patients continue to suffer from progressive kidney damage. Chronic hyperglycemia is the main driver of changes observed in diabetes; however, it was recently discovered that inflammation and oxidative stress contribute to the development and progression of kidney damage. Therefore, it is important to search for new pharmacological therapies that stop the progression of DN. Sodium tungstate (NaW) is an effective short and long-term antidiabetic agent in both type 1 and type 2 diabetes models.
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