Activation of the SST-SSTR5 Signaling Pathway Enhances Corneal Wound Healing in Diabetic Mice

伤口愈合 医学 信号转导 生物信息学 生物 细胞生物学 免疫学
作者
Xinwei Chen,Yan Li,Liyuan Lu,Jiaxin Wu,Ruyu Yan,Jiayan Xiang,Qiwei Fan,Jiangman Liu,Senmao Li,Yunxia Xue,Ting Fu,Jun Liu,Zhijie Li
出处
期刊:Mucosal Immunology [Elsevier BV]
被引量:1
标识
DOI:10.1016/j.mucimm.2024.06.002
摘要

Corneal wound healing in diabetic patients is usually delayed and accompanied by excessive inflammation. However, the underlying cellular and molecular mechanisms remain poorly understood. Here, we found that somatostatin (SST), an immunosuppressive peptide produced by corneal nerve fibers, was significantly reduced in streptozotocin-induced diabetic mice. In addition, we discovered that topical administration of exogenous SST significantly improved re-epithelialization and nerve regeneration following diabetic corneal epithelial abrasion. Further analysis showed that topical SST significantly reduced the expression of injury inflammation-related genes, inhibited neutrophil infiltration, and shifted macrophage polarization from pro-inflammatory M1 to anti-inflammatory M2 in diabetic corneas' healing. Moreover, the application of L-817,818, an agonist of the SST receptor type 5 subtype, significantly reduced the inflammatory response following epithelial injury and markedly improved the process of re-epithelialization and nerve regeneration in mice. Taken together, these data suggest that activation of the SST-SST receptor type 5 pathway significantly ameliorates diabetes-induced abnormalities in corneal wound repair in mice. Targeting this pathway may provide a novel strategy to restore impaired corneal wound closure and nerve regeneration in diabetic patients.
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