亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Amygdala structural and functional reorganization as an indicator of affective dysfunction in patients with tinnitus

部分各向异性 耳鸣 扁桃形结构 功能磁共振成像 白质 心理学 磁共振成像 神经科学 基础(医学) 听力学 基底神经节 医学 内科学 中枢神经系统 放射科 胰岛素
作者
Yan Huang,Qian Chen,Han Lv,Zhaodi Wang,Xinghao Wang,Chunli Liu,Yuyou Huang,Pengfei Zhao,Zhenghan Yang,Shusheng Gong,Zhenchang Wang
出处
期刊:Human Brain Mapping [Wiley]
卷期号:45 (8) 被引量:1
标识
DOI:10.1002/hbm.26712
摘要

Abstract The aim of this study was to systematically investigate structural and functional alterations in amygdala subregions using multimodal magnetic resonance imaging (MRI) in patients with tinnitus with or without affective dysfunction. Sixty patients with persistent tinnitus and 40 healthy controls (HCs) were recruited. Based on a questionnaire assessment, 26 and 34 patients were categorized into the tinnitus patients with affective dysfunction (TPAD) and tinnitus patients without affective dysfunction (TPWAD) groups, respectively. MRI‐based measurements of gray matter volume, fractional anisotropy (FA), fractional amplitude of low‐frequency fluctuations (fALFF), regional homogeneity (ReHo), degree centrality (DC), and functional connectivity (FC) were conducted within 14 amygdala subregions for intergroup comparisons. Associations between the MRI properties and clinical characteristics were estimated via partial correlation analyses. Compared with that of the HCs, the TPAD and TPWAD groups exhibited significant structural and functional changes, including white matter integrity (WMI), fALFF, ReHo, DC, and FC alterations, with more pronounced WMI changes in the TPAD group, predominantly within the left auxiliary basal or basomedial nucleus (AB/BM), right central nucleus, right lateral nuclei (dorsal portion), and left lateral nuclei (ventral portion containing basolateral portions). Moreover, the TPAD group exhibited decreased FC between the left AB/BM and left middle occipital gyrus and right superior frontal gyrus (SFG), left basal nucleus and right SFG, and right lateral nuclei (intermediate portion) and right SFG. In combination, these amygdalar alterations exhibited a sensitivity of 65.4% and specificity of 96.9% in predicting affective dysfunction in patients with tinnitus. Although similar structural and functional amygdala remodeling were observed in the TPAD and TPWAD groups, the changes were more pronounced in the TPAD group. These changes mainly involved alterations in functionality and white matter microstructure in various amygdala subregions; in combination, these changes could serve as an imaging‐based predictor of emotional disorders in patients with tinnitus.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Kashing完成签到,获得积分10
1秒前
CNS_Fighter88发布了新的文献求助10
2秒前
6秒前
l123完成签到,获得积分10
10秒前
CYC完成签到 ,获得积分10
13秒前
zhao完成签到 ,获得积分10
15秒前
脑洞疼应助l123采纳,获得10
18秒前
大个应助守仁则阳明采纳,获得10
21秒前
33秒前
木有完成签到 ,获得积分10
34秒前
34秒前
科研通AI5应助10 g采纳,获得10
37秒前
Zoe发布了新的文献求助30
37秒前
39秒前
Zoe完成签到,获得积分10
45秒前
糖伯虎完成签到 ,获得积分10
46秒前
量子星尘发布了新的文献求助10
47秒前
49秒前
l123发布了新的文献求助10
53秒前
wys完成签到,获得积分10
59秒前
淡漠完成签到 ,获得积分10
1分钟前
华仔应助守仁则阳明采纳,获得10
1分钟前
1分钟前
liudy完成签到,获得积分10
1分钟前
852应助lf采纳,获得10
1分钟前
li发布了新的文献求助10
1分钟前
liudy发布了新的文献求助10
1分钟前
沉默白桃完成签到 ,获得积分10
1分钟前
1分钟前
li完成签到,获得积分10
1分钟前
1分钟前
1分钟前
Akim应助科研通管家采纳,获得10
1分钟前
小马甲应助科研通管家采纳,获得10
1分钟前
lf发布了新的文献求助10
1分钟前
明亮猫咪发布了新的文献求助10
1分钟前
orixero应助江洋大盗采纳,获得10
1分钟前
杨紫欣完成签到 ,获得积分10
1分钟前
早睡一哥完成签到,获得积分10
1分钟前
江洋大盗完成签到,获得积分10
1分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3976608
求助须知:如何正确求助?哪些是违规求助? 3520700
关于积分的说明 11204542
捐赠科研通 3257350
什么是DOI,文献DOI怎么找? 1798716
邀请新用户注册赠送积分活动 877881
科研通“疑难数据库(出版商)”最低求助积分说明 806613