活性氧
瓦勒氏变性
细胞生物学
周围神经损伤
自噬
线粒体
癌症研究
坐骨神经
神经科学
化学
医学
再生(生物学)
细胞凋亡
生物化学
内科学
生物
作者
Renliang Zhao,Xiangtian Deng,Yunfeng Tang,Xiaozhong Yang,Zilu Ge,Dong Wang,Yifan Shen,Lianghua Jiang,Wei Lin,Zheng Cheng,G.F. Wang
出处
期刊:ACS Nano
[American Chemical Society]
日期:2024-06-18
卷期号:18 (26): 16556-16576
标识
DOI:10.1021/acsnano.3c13102
摘要
Critical peripheral nerve deficiencies present as one of the most formidable conundrums in the realm of clinical medicine, frequently culminating in structural degradation and derangement of the neuromuscular apparatus. Engineered extracellular vesicles (EVs) exhibit the potential to ameliorate nerve impairments. However, the advent of Wallerian degeneration (WD), an inexorable phenomenon that ensues post peripheral nerve injury, serves as an insurmountable impediment to the direct therapeutic efficacy of EVs. In this investigation, we have fashioned a dynamic network for the conveyance of PTEN-induced kinase 1 (PINK1) mRNA (E-EV-P@HPCEP) using an adaptive hydrogel with reactive oxygen species (ROS)/Ca
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