双吖丙啶
化学
纳米技术
组合化学
化学改性
立体化学
材料科学
生物化学
作者
Yan Tan,Songsen Fu,Tao Yang,Yuxin Xie,Guyi Shen,Jie Yan,Yufen Zhao,Feng Ni
摘要
A series of site-diversified, fully functionalized diazirine probes are constructed based on a scaffold shared by several marketed EGFR-targeted drugs. The integrated analysis of protein targets of the site-diversified probe toolkit not only unveils more complete target space and helps suggest false positive targets, but also reveals dynamic events of multi-domain target-ligand interaction.
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