PI3K/AKT/mTOR通路
医学
神经母细胞瘤
蛋白激酶B
癌症研究
信号通路
癌症
信号转导
生物信息学
内科学
细胞生物学
生物
受体
遗传学
细胞培养
作者
David King,Daniel Yeomanson,Helen E. Bryant
出处
期刊:Journal of Pediatric Hematology Oncology
[Ovid Technologies (Wolters Kluwer)]
日期:2015-05-01
卷期号:37 (4): 245-251
被引量:188
标识
DOI:10.1097/mph.0000000000000329
摘要
Neuroblastoma is the most common extracranial cancer in childhood. High-risk neuroblastoma continues to have a poor prognosis and there is an urgent need to design biologically based therapies that specifically target the pathways responsible for malignant transformation and progression. One such pathway is the PI3K/Akt/mTOR pathway. In this article we outline the evidence for aberrant activation of the PI3K/Akt/mTOR pathway in neuroblastoma and discuss the possible mechanisms which mediate it. We also discuss the development of treatments targeting this pathway in neuroblastoma and the challenges that must be overcome before such treatments can enter routine clinical practice.
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