2-Chloro-2,2-difluoroacetophenone

[384-67-8] C8H5ClF2O (MW 190.56) InChI = 1S/C8H5ClF2O/c9-8(10,11)7(12)6-4-2-1-3-5-6/h1-5H InChIKey = MNOONJNILVDLSW-UHFFFAOYSA-N (precursor for the preparation of 2,2-difluoro enol silyl ethers or 2,2-difluoro enol silyl phosphates;9-12 difluorocarbene precursor;6 precursor for the synthesis of gem-difluoromethene-containing compounds13-22) Physical Data: colorless liquid; bp 84–85 °C/25 mmHg.1 Solubility: sol alcohols, ethers, CH2Cl2, CHCl3, benzene, toluene, acetonitrile, DMF, and DMSO. Form Supplied in: colorless liquid; often prepared by the reaction between chlorodifluoroacetic acid and PhMgBr,2-5 or prepared by chlorination of [2,2-difluoro-1-[(trimethylsilyl)oxy]ethenyl]benzene.6 Handling, Storage, and Precautions: 2-chloro-2,2-difluoroacetophenone (PhCOCF2Cl) has high reactivity with bases, nucleophiles, reducing agents, and single-electron transferring agent; store under anhydrous, neutral conditions; use in a fume hood.