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Evaluation of the interaction between anti-apoptotic Bcl-2 protein family mRNA expression and autophagy gene Bcl-1 expression in Egyptian SLE patients

医学 细胞凋亡 自噬 系统性红斑狼疮 信使核糖核酸 内科学 免疫学 红斑狼疮 基因 疾病 抗体 生物 生物化学
作者
Noha M. Khalil,Rasha Nazih Yousef,Hecham Gamal AlDeen,Mervat Essam Behiry,Ingy Ashmawy,Abeer Ramadan,Eman Awadallah,Asmaa Ali,Alshaimaa R. Alnaggar
出处
期刊:Lupus [SAGE]
卷期号:31 (10): 1186-1190
标识
DOI:10.1177/09612033221106302
摘要

Objectives Autophagy is a complex cellular process that maintains homeostasis in systemic lupus erythematosus. Abnormally high expression of Bcl-2 was observed in B and T lymphocytes in the peripheral blood in SLE patients. These may be responsible for the survival of self-reactive lymphocytes and the development of lupus, and the study aims at evaluating interaction between apoptosis and autophagy in Egyptian lupus patients. Methods Sixty patients with SLE were diagnosed by fulfilling the Systemic Lupus International Collaborating Clinics (SLICC) classification criteria for SLE and sixty healthy age and sex matched control. All patients were subjected to full medical history and clinical examination. Activity was assessed using SLEDAI-2K score. Gene expression of Beclin-1, Bcl-2-L2, and Bcl-2 was measured. Results The study revealed that the expression of anti-apoptotic Bcl-2 and Bcl-2-L2 was significantly higher in SLE patients than control subjects, as well as the major apoptotic agent (Beclin-1) mRNA, p = 0.03, < 0.001 and 0.02, respectively. The apoptotic Beclin-1 mRNA was positively correlated with SLE disease severity index, r = 0.25; p = 0.0.4; therefore, our results showed that expression of the Beclin-1 was significantly higher in SLE patients than control ( p < 0.02). Conclusion Our results showed that expression of the Beclin 1 were significantly higher in SLE patients than control ( p < 0.02).
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