过氧亚硝酸盐
荧光
硝基酪氨酸
超分子化学
苯并咪唑
活性氮物种
化学
检出限
生物标志物
共价键
生物化学
氧化应激
有机化学
色谱法
酶
分子
一氧化氮合酶
物理
量子力学
超氧化物
作者
Lidia A. Pérez‐Márquez,Marcelle D. Perretti,Raúl García‐Rodríguez,F.J. Lahoz,Romen Carrillo
标识
DOI:10.1002/ange.202205403
摘要
Abstract 3‐Nitrotyrosine (NT) is generated by the action of peroxynitrite and other reactive nitrogen species (RNS), and as a consequence it is accumulated in inflammation‐associated conditions. This is particularly relevant in kidney disease, where NT concentration in blood is considerably high. Therefore, NT is a crucial biomarker of renal damage, although it has been underestimated in clinical diagnosis due to the lack of an appropriate sensing method. Herein we report the first fluorescent supramolecular sensor for such a relevant compound: Fluorescence by rotational restriction of tetraphenylethenes (TPE) in a covalent cage is selectively quenched in human blood serum by 3‐nitrotyrosine (NT) that binds to the cage with high affinity, allowing a limit of detection within the reported physiological concentrations of NT in chronic kidney disease.
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