Universal <scp>HBV</scp> vaccination dramatically reduces the prevalence of <scp>HBV</scp> infection and incidence of hepatocellular carcinoma

医学 接种疫苗 肝细胞癌 乙型肝炎表面抗原 入射(几何) 乙型肝炎病毒 队列 乙型肝炎 免疫学 内科学 回顾性队列研究 队列研究 病毒学 病毒 光学 物理
作者
Grace Lai-Hung Wong,Vicki Wing‐Ki Hui,Thomas Yip,Lilian Yan Liang,Xinrong Zhang,Yee-Kit Tse,Joseph K. L. Lai,H.L.W. Chan,V. W. S. Wong
出处
期刊:Alimentary Pharmacology & Therapeutics [Wiley]
卷期号:56 (5): 869-877 被引量:5
标识
DOI:10.1111/apt.17120
摘要

Universal vaccination of newborns with hepatitis B virus (HBV) vaccine is the most important strategy to prevent chronic HBV infection and its complications of which hepatocellular carcinoma (HCC) as the deadliest.To evaluate the impact of universal HBV vaccination on the prevalence of chronic HBV infection, and the incidences of HCC and hepatic events in young adults born before and after the introduction of the universal HBV vaccination programme in 1988 in Hong Kong METHODS: This was a territory-wide retrospective observational cohort study of consecutive adult subjects born in 1970-2002 with hepatitis B surface antigen (HBsAg) checked. Subjects born during the vaccination era (1988-2002) were included in the vaccinated cohort; subjects born between 1970 and 1987 were included in the unvaccinated cohort.We included 695,925 subjects for HBV prevalence analysis. Chronic HBV infection dropped from 14.3% in subjects born in 1970, to 6.7% in subjects born in 1988. In total, 53,960 vaccinated and 318,290 unvaccinated subjects who had available clinical data were included for event analysis. HCC and hepatic events occurred in 44 (0.1%) and 75 (0.1%) of the vaccinated subjects and in 1305 (0.4%) and 1806 (0.6%) of the unvaccinated subjects, respectively. All incidence rates remained numerically lower in vaccinated subjects after adjustment for age, gender and antiviral treatment, but failed to reach statistical significance due to very low incidence rates.Universal HBV vaccination markedly reduces the prevalence of chronic HBV infection and may contribute to the decreased incidences of HCC and hepatic events.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
冯珂完成签到 ,获得积分10
1秒前
BK_201完成签到,获得积分10
1秒前
xdc完成签到,获得积分10
2秒前
abiorz完成签到,获得积分0
2秒前
TianFuAI完成签到,获得积分10
2秒前
窗外是蔚蓝色完成签到,获得积分0
3秒前
Helios完成签到,获得积分10
3秒前
风信子完成签到,获得积分10
4秒前
xueshidaheng完成签到,获得积分0
7秒前
qiuer0011完成签到,获得积分10
7秒前
静默向上发布了新的文献求助10
8秒前
吐司炸弹完成签到,获得积分10
8秒前
mayfly完成签到,获得积分10
8秒前
Brief完成签到,获得积分10
8秒前
nanostu完成签到,获得积分10
8秒前
科研狗的春天完成签到 ,获得积分10
9秒前
自来也完成签到,获得积分10
9秒前
愛研究完成签到,获得积分10
10秒前
Amikacin完成签到,获得积分10
10秒前
鹏举瞰冷雨完成签到,获得积分10
10秒前
缥缈的冰旋完成签到,获得积分10
10秒前
呆萌的太阳完成签到 ,获得积分10
11秒前
天明完成签到,获得积分10
12秒前
Acid完成签到 ,获得积分10
12秒前
碳土不凡完成签到 ,获得积分10
12秒前
14秒前
中华牌老阿姨完成签到,获得积分0
14秒前
光之霓裳完成签到 ,获得积分10
14秒前
立冬完成签到,获得积分10
15秒前
木九黎完成签到,获得积分10
16秒前
yy14207发布了新的文献求助10
17秒前
ShellyMaya完成签到 ,获得积分10
17秒前
影流完成签到,获得积分10
18秒前
游大达完成签到,获得积分0
18秒前
keyanbrant完成签到 ,获得积分10
19秒前
田1986完成签到,获得积分10
19秒前
完犊子发布了新的文献求助10
20秒前
仁爱的觅夏完成签到,获得积分10
21秒前
23秒前
大树下的小鸟完成签到,获得积分10
24秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968578
求助须知:如何正确求助?哪些是违规求助? 3513393
关于积分的说明 11167478
捐赠科研通 3248836
什么是DOI,文献DOI怎么找? 1794499
邀请新用户注册赠送积分活动 875131
科研通“疑难数据库(出版商)”最低求助积分说明 804664