Risk Factors for Spinal Structural Damage in a Chinese Cohort With Ankylosing Spondylitis

医学 强直性脊柱炎 体质指数 内科学 单变量分析 列线图 骶髂关节炎 射线照相术 脊柱炎 队列 外科 多元分析
作者
Weiping Kong,Caroline A. Jefferies,Thomas J. Learch,Xiaowei Gan,Feng Zhu,Nan Zhang,Dier Jin,Yingze Zhang,Qingwen Tao,Xiaoping Yan,Mariko Ishimori,Michael H. Weisman
出处
期刊:Jcr-journal of Clinical Rheumatology [Lippincott Williams & Wilkins]
卷期号:28 (1): e118-e124 被引量:4
标识
DOI:10.1097/rhu.0000000000001658
摘要

A cross-sectional study was conducted in 270 Chinese patients with ankylosing spondylitis (AS) in order to identify potential risk factors for severity of spinal structural damage.Two hundred seventy AS patients fulfilled the Modified New York Criteria. Computed tomography (CT) was used to scan sacroiliac and hip joints, and radiography was used to scan anteroposterior and lateral lumbar spine, as well as lateral cervical spine. Bath Ankylosing Spondylitis Radiology Index and modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) were scored in duplicate.One hundred eighty-three patients had low mSASSS (mSASSS, <10), and 87 patients had high mSASSS (mSASSS, ≥10). Univariate analysis revealed that AS age of onset, body mass index (BMI), smoking duration, duration of symptoms, diagnostic delay, hip involvement, and sacroiliitis grade were significantly associated with the risk of having high mSASSS after adjustment (all p's < 0.05). Hip involvement interacted significantly with BMI and smoking duration in a graded manner. Particularly, relative to patients with low BMI-negative hip involvement, those with high BMI-negative hip involvement, low BMI-positive hip involvement, and high BMI-positive hip involvement had a 1.94-fold, 3.29-fold, and 5.07-fold increased risk of high mSASSS (95% confidence interval, 0.84-4.47, 1.37-7.89, and 1.97-13.06, p = 0.118, 0.008, and 0.001, respectively). Finally, a nomogram graph based on 7 significant risk factors was generated with substantial prediction accuracy (concordance index, 0.906).We have identified 7 potential risk factors for the severity of spinal structural damage in Chinese AS patients. Importantly, positive hip involvement, combined with high BMI or long smoking duration, was associated with a remarkably increased risk of having severe spinal structural damage.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
dong应助Yuelong采纳,获得10
4秒前
bingsu108完成签到,获得积分10
5秒前
小岚花发布了新的文献求助10
7秒前
CodeCraft应助凉茶采纳,获得10
7秒前
脑洞疼应助YZQ采纳,获得10
8秒前
琳琳完成签到,获得积分10
8秒前
华仔应助俏皮的白柏采纳,获得10
9秒前
羊洋洋完成签到,获得积分20
9秒前
最爱地瓜和虾滑完成签到 ,获得积分10
11秒前
yar给聪慧的草丛的求助进行了留言
11秒前
奋斗雁山发布了新的文献求助10
11秒前
12秒前
查到文献了吗完成签到,获得积分10
12秒前
FashionBoy应助Lee采纳,获得10
12秒前
Elvira完成签到,获得积分10
12秒前
14秒前
16秒前
易酰水烊酸应助Onism采纳,获得10
16秒前
青岚完成签到 ,获得积分10
16秒前
17秒前
tay发布了新的文献求助10
18秒前
19秒前
pluto应助一直小虾米采纳,获得10
19秒前
双楠应助不想采纳,获得10
21秒前
22秒前
Luobing完成签到,获得积分10
23秒前
研友_LXjjOZ完成签到,获得积分10
23秒前
上官若男应助蔚蓝的天空采纳,获得10
24秒前
slr完成签到,获得积分10
24秒前
逆境发布了新的文献求助10
24秒前
25秒前
草莓布丁发布了新的文献求助80
26秒前
凉茶发布了新的文献求助10
27秒前
27秒前
29秒前
29秒前
29秒前
29秒前
yyyq发布了新的文献求助10
30秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988838
求助须知:如何正确求助?哪些是违规求助? 3531250
关于积分的说明 11252914
捐赠科研通 3269838
什么是DOI,文献DOI怎么找? 1804820
邀请新用户注册赠送积分活动 881943
科研通“疑难数据库(出版商)”最低求助积分说明 809028