Risk Factors for Spinal Structural Damage in a Chinese Cohort With Ankylosing Spondylitis

医学 强直性脊柱炎 体质指数 内科学 单变量分析 列线图 骶髂关节炎 射线照相术 脊柱炎 队列 外科 多元分析
作者
Weiping Kong,Caroline A. Jefferies,Thomas J. Learch,Xiaowei Gan,Feng Zhu,Nan Zhang,Dier Jin,Yingze Zhang,Qingwen Tao,Xiaoping Yan,Mariko Ishimori,Michael H. Weisman
出处
期刊:Jcr-journal of Clinical Rheumatology [Lippincott Williams & Wilkins]
卷期号:28 (1): e118-e124 被引量:4
标识
DOI:10.1097/rhu.0000000000001658
摘要

A cross-sectional study was conducted in 270 Chinese patients with ankylosing spondylitis (AS) in order to identify potential risk factors for severity of spinal structural damage.Two hundred seventy AS patients fulfilled the Modified New York Criteria. Computed tomography (CT) was used to scan sacroiliac and hip joints, and radiography was used to scan anteroposterior and lateral lumbar spine, as well as lateral cervical spine. Bath Ankylosing Spondylitis Radiology Index and modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) were scored in duplicate.One hundred eighty-three patients had low mSASSS (mSASSS, <10), and 87 patients had high mSASSS (mSASSS, ≥10). Univariate analysis revealed that AS age of onset, body mass index (BMI), smoking duration, duration of symptoms, diagnostic delay, hip involvement, and sacroiliitis grade were significantly associated with the risk of having high mSASSS after adjustment (all p's < 0.05). Hip involvement interacted significantly with BMI and smoking duration in a graded manner. Particularly, relative to patients with low BMI-negative hip involvement, those with high BMI-negative hip involvement, low BMI-positive hip involvement, and high BMI-positive hip involvement had a 1.94-fold, 3.29-fold, and 5.07-fold increased risk of high mSASSS (95% confidence interval, 0.84-4.47, 1.37-7.89, and 1.97-13.06, p = 0.118, 0.008, and 0.001, respectively). Finally, a nomogram graph based on 7 significant risk factors was generated with substantial prediction accuracy (concordance index, 0.906).We have identified 7 potential risk factors for the severity of spinal structural damage in Chinese AS patients. Importantly, positive hip involvement, combined with high BMI or long smoking duration, was associated with a remarkably increased risk of having severe spinal structural damage.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
桐桐应助Bismarck采纳,获得10
4秒前
CLY完成签到,获得积分10
5秒前
6秒前
rita_sun1969完成签到,获得积分10
7秒前
研友_8K2QJZ完成签到,获得积分10
7秒前
蝴蝶完成签到 ,获得积分10
8秒前
ARIA完成签到 ,获得积分10
8秒前
大橙子发布了新的文献求助10
11秒前
Bismarck完成签到,获得积分20
12秒前
12秒前
爱笑子默完成签到,获得积分10
13秒前
13秒前
一点完成签到,获得积分10
15秒前
研友_VZG7GZ应助大葱鸭采纳,获得10
15秒前
DezhaoWang完成签到,获得积分10
16秒前
知犯何逆发布了新的文献求助10
17秒前
原本完成签到,获得积分10
17秒前
Bismarck发布了新的文献求助10
18秒前
苗条丹南完成签到 ,获得积分10
20秒前
yu完成签到 ,获得积分10
23秒前
skyleon完成签到,获得积分10
23秒前
无心的天真完成签到 ,获得积分10
24秒前
Engen完成签到,获得积分20
24秒前
25秒前
学术小垃圾完成签到,获得积分10
25秒前
dreamwalk完成签到 ,获得积分10
25秒前
黄淮科研小白龙完成签到 ,获得积分10
26秒前
齐嫒琳完成签到,获得积分10
28秒前
研友_Lav0Qn完成签到,获得积分10
28秒前
大橙子发布了新的文献求助10
29秒前
GreenT完成签到,获得积分10
29秒前
鳄鱼队长完成签到,获得积分10
30秒前
Zengyuan完成签到,获得积分10
30秒前
研友_Lav0Qn发布了新的文献求助10
31秒前
perry4rosa完成签到,获得积分0
31秒前
量子星尘发布了新的文献求助10
32秒前
LIFE2020完成签到 ,获得积分10
32秒前
科研人完成签到,获得积分10
33秒前
飞云完成签到 ,获得积分10
34秒前
满天星辰独览完成签到 ,获得积分10
34秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038157
求助须知:如何正确求助?哪些是违规求助? 3575869
关于积分的说明 11373842
捐赠科研通 3305650
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022