小RNA
生物
自身免疫
FOXP3型
实验性自身免疫性脑脊髓炎
抑制因子
细胞生物学
非编码RNA
调节器
核糖核酸
肽
免疫系统
基因表达
基因
遗传学
生物化学
作者
Hong Zhou,Fangzhou Lou,Jing Bai,Yang-Kook Sun,Wei Cai,Libo Sun,Zhenyao Xu,Zhaoyuan Liu,Lingyun Zhang,Qianqian Yin,Junxun Zhang,Yuanyuan Gao,Zhikai Wang,Liman Niu,Xiaojie Cai,Deng Siyu,Hong Wang,Li Xia,Florent Ginhoux,Qun Li,Hong Wang
标识
DOI:10.15252/embr.202153475
摘要
Recent evidence has revealed that small polypeptides (containing fewer than 100 amino acids) can be translated from noncoding RNAs (ncRNAs), which are usually defined as RNA molecules that do not encode proteins. However, studies on functional products translated from primary transcripts of microRNA (pri-miRNA) are quite limited. Here, we describe a peptide termed miPEP31 that is encoded by pri-miRNA-31. miPEP31 is highly expressed in Foxp3+ regulatory T cells (Tregs ) and significantly promotes the differentiation of Tregs without affecting their inhibitory ability. Our results show that miPEP31 is a cell-penetrating peptide both in vitro and in vivo. miPEP31 downregulates miR-31 expression, enhances peripheral Treg induction, and dramatically suppresses experimental autoimmune encephalomyelitis. Mechanistically, we show that miPEP31 acts as a transcriptional repressor inhibiting the expression of miRNA-31, a negative regulator of Tregs . Our results reveal an indispensable role of miPEP31 in maintaining immune homeostasis by promoting Treg differentiation and also present a potential therapeutic peptide for modulating miRNA expression and treating autoimmune diseases.
科研通智能强力驱动
Strongly Powered by AbleSci AI