生物
Notch信号通路
转录因子
影像盘
细胞生物学
亮氨酸拉链
电池极性
遗传学
ATF3
Notch蛋白质类
信号转导
癌症研究
作者
Rémi Logeay,Charles Géminard,Patrice Lassus,Miriam Rodríguez-Vázquez,Diala Kantar,Lisa Heron-Milhavet,Bettina Fischer,Sarah J. Bray,Jacques Colinge,Alexandre Djiane
出处
期刊:Development
[The Company of Biologists]
日期:2022-01-10
摘要
Aggressive neoplastic growth can be initiated by a limited number of genetic alterations, such as the well-established cooperation between loss of cell architecture and hyperactive signaling pathways. However, our understanding of how these different alterations interact and influence each other remains very incomplete. Using Drosophila paradigms of imaginal wing disc epithelial growth, we have monitored the changes in Notch pathway activity according to the polarity status of cells (scrib mutant). We show that the scrib mutation impacts the direct transcriptional output of the Notch pathway, without altering the global distribution of Su(H), the Notch-dedicated transcription factor. The Notch-dependent neoplasms require, however, the action of a group of transcription factors, similar to those previously identified for Ras/scrib neoplasm (namely AP-1, Stat92E, Ftz-F1 and basic leucine zipper factors), further suggesting the importance of this transcription factor network during neoplastic growth. Finally, our work highlights some Notch/scrib specificities, in particular the role of the PAR domain-containing basic leucine zipper transcription factor and Notch direct target Pdp1 for neoplastic growth.
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