伤口愈合
血管生成
材料科学
自愈水凝胶
再生(生物学)
聚乙烯醇
离子液体
生物医学工程
化学
医学
细胞生物学
癌症研究
免疫学
高分子化学
复合材料
生物
生物化学
催化作用
作者
Bin Liu,Rongzhan Fu,Zhiguang Duan,Chenhui Zhu,Jianjun Deng,Daidi Fan
标识
DOI:10.1016/j.compositesb.2022.109804
摘要
Bacterial colonization, prolonged inflammatory phase, angiogenesis difficulties, collagen deposition deficiency, and other serious complications can impede the infected wound repair process, particularly for infected wounds of diabetic patients. Electrical stimulation (ES), as an attractive emerging therapy, has been widely carried out for promoting skin regeneration. Herein, we constructed a conductive antibacterial multifunctional hydrogel combined with exogenous ES as a strategy for Staphylococcus aureus-infected wound healing. The hydrogel is composed of an ionic liquid (1-Vinyl-3-butylimidazolium bromide, [VBIM]Br) polymer network and a polyvinyl alcohol (PVA)-borax dynamic borate network. The [VBIM]Br conferred the hydrogel with excellent electrical conductivity to favor the introduction of ES therapy for wound healing. Moreover, the ionic liquid polymer network endowed the hydrogel with anti-bacterial abilities to kill bacteria, anti-inflammatory capacities to shorten the inflammation period, high transparency to observe the healing process, and excellent protein absorption ability. The dynamic borate bonds in the PVA network provided the hydrogel with self-healing and tissue adhesion properties. Furthermore, the [VBIM]Br composite hydrogel coupled with exogenous ES promoted cell proliferation, migration, angiogenesis, and collagen deposition, which demonstrated great potential in chronic diabetic infected wound repair.
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