化学
卤化物
二硫代氨基甲酸盐
催化作用
光催化
过渡金属
产量(工程)
SN2反应
金属卤化物
吲唑
组合化学
光化学
有机化学
材料科学
冶金
作者
Panjie Xiang,Kai Sun,Shuang Wang,Xiaolan Chen,Lingbo Qu,Bing Yu
标识
DOI:10.1016/j.cclet.2022.03.096
摘要
An SN2-based photochemical strategy using dithiocarbamate anion as catalyst was developed for the activation of benzyl halides, which are extremely challenging to be applied as radical precursors in visible light photocatalysis. With this transition-metal-free and oxidant-free protocol, the benzylation (or cyanomethylation) of various heterocycles including quinoxalin-2(1H)-ones, coumarin, 2-phenyl-2H-indazole, 1-methyl-5-phenylpyrazin-2(1H)-one, 1-(fluoromethyl)cinnolin-4(1H)-one, and 2,4-dibenzyl-1,2,4-triazine-3,5(2H,4H)‑dione could be realized (46 examples, up to 98% yield). Importantly, some biologically relevant 3-benzylquinoxalin-2(1H)-ones were also be synthesized under mild conditions.
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