肉汤微量稀释
棋盘
琼脂稀释
琼脂稀释法
琼脂
抗菌剂
最小抑制浓度
稀释
色谱法
连续稀释
抗菌活性
化学
微生物学
琼脂扩散试验
食品科学
生物
细菌
医学
遗传学
物理
替代医学
病理
热力学
出处
期刊:ASM Press eBooks
[ASM Press]
日期:2016-01-27
卷期号:: 5.16.1-5.16.23
被引量:14
标识
DOI:10.1128/9781555818814.ch5.16
摘要
Microbiologists commonly use a two-dimensional, two-agent broth microdilution checkerboard to evaluate combinations of antimicrobial agents against microorganisms. A broth macrodilution limited series, agar dilution method, or disk diffusion method can also be used. Test methods are based on CLSI broth dilution susceptibility methods (1) for evaluating the inhibitory or bactericidal activity (2) of specific concentrations in combination at a fixed time. In vitro interactions are calculated algebraically and interpreted as synergistic, indifferent, or antagonistic depending on whether the antibacterial activity of the combination is greater than, equivalent to, or less than the activities of the individual agents, respectively. In vitro interactions can also be represented geometrically with isobolograms (3).
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