免疫系统
抗原
免疫疗法
光热治疗
癌症免疫疗法
免疫学
癌症研究
肿瘤微环境
生物
肿瘤抗原
材料科学
纳米技术
作者
Yao Li,Kaiyue Zhang,Yao Wu,Yale Yue,Keman Cheng,Qingqing Feng,Xiaotu Ma,Jie Liang,Nana Ma,Guangna Liu,Guangjun Nie,Lei Ren,Xiao Zhao
出处
期刊:Small
[Wiley]
日期:2022-02-12
卷期号:18 (14)
被引量:79
标识
DOI:10.1002/smll.202107461
摘要
Tumor antigens released from tumor cells after local photothermal therapy (PTT) can activate the tumor-specific immune responses, which are critical for eliminating the residual lesions and distant metastases. However, the limited recognition efficiency of released tumor antigens by the immune system and the immunosuppressive microenvironment lead to ineffective antitumor immunity. Here, an in situ multifunctional vaccine based on bacterial outer membrane vesicles (OMVs, 1-MT@OMV-Mal) is developed by surface conjunction of maleimide groups (Mal) and interior loading with inhibitor of indoleamine 2, 3-dioxygenase (IDO), 1-methyl-tryptophan (1-MT). 1-MT@OMV-Mal can bind to the released tumor antigens after PTT, and be efficiently recognized and taken up by dendritic cells. Furthermore, in situ injection of 1-MT@OMV-Mal simultaneously overcomes the immune inhibition of IDO on tumor-infiltrating effector T cells, leading to remarkable inhibition on both primary and distant tumors. Together, a promising in situ vaccine based on OMVs to facilitate immune-mediated tumor clearance after PTT through orchestrating antigen capture and immune modulation is presented.
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