Acute ischaemic stroke associated with SARS-CoV-2 infection in North America

医学 改良兰金量表 冲程(发动机) 内科学 缺血性中风 2019年冠状病毒病(COVID-19) 糖尿病 临床终点 队列 回顾性队列研究 儿科 缺血性中风 临床试验 缺血 疾病 传染病(医学专业) 内分泌学 工程类 机械工程
作者
Adam A. Dmytriw,Mahmoud Dibas,Kevin Phan,Aslan Efendizade,Johanna Ospel,Clemens M. Schirmer,Fabio Settecase,Manraj K.S. Heran,Anna Luisa Kühn,Ajit S Puri,Bijoy K. Menon,Sanjeev Sivakumar,Ashkan Mowla,Daniel Vela‐Duarte,Italo Linfante,Guilherme Dabus,Robert W. Regenhardt,Salvatore D’Amato,Joseph Rosenthal,Alicia Zha,Nafee T. Talukder,Sunil A. Sheth,Ameer E Hassan,Daniel L. Cooke,Lester Y. Leung,Adel M. Malek,Barbara Voetsch,Siddharth Sehgal,Ajay K. Wakhloo,Mayank Goyal,Hannah Wu,Jake Cohen,Sherief Ghozy,David Turkel‐Parella,Zerwa Farooq,Justin E. Vranic,James D. Rabinov,Christopher J. Stapleton,Ramandeep Minhas,Vinodkumar Velayudhan,Zeshan A. Chaudhry,Andrew Xavier,María Bres Bullrich,Sachin Pandey,Luciano A. Sposato,Stephen A. Johnson,Gaurav Gupta,Priyank Khandelwal,Latisha K. Ali,David S. Liebeskind,Mudassir Farooqui,Santiago Ortega‐Gutiérrez,Fadi Nahab,Dinesh Jillella,Karen Chen,Mohammad Ali Aziz‐Sultan,Mohamad Abdalkader,Artem Kaliaev,Thanh N. Nguyen,Diogo C Haussen,Raul G Nogueira,Israr Ul Haq,Osama O. Zaidat,Emma Sanborn,Thabele M Leslie‐Mazwi,Aman B. Patel,James E. Siegler,Ambooj Tiwari
出处
期刊:Journal of Neurology, Neurosurgery, and Psychiatry [BMJ]
卷期号:93 (4): 360-368 被引量:32
标识
DOI:10.1136/jnnp-2021-328354
摘要

To analyse the clinical characteristics of COVID-19 with acute ischaemic stroke (AIS) and identify factors predicting functional outcome.Multicentre retrospective cohort study of COVID-19 patients with AIS who presented to 30 stroke centres in the USA and Canada between 14 March and 30 August 2020. The primary endpoint was poor functional outcome, defined as a modified Rankin Scale (mRS) of 5 or 6 at discharge. Secondary endpoints include favourable outcome (mRS ≤2) and mortality at discharge, ordinal mRS (shift analysis), symptomatic intracranial haemorrhage (sICH) and occurrence of in-hospital complications.A total of 216 COVID-19 patients with AIS were included. 68.1% (147/216) were older than 60 years, while 31.9% (69/216) were younger. Median [IQR] National Institutes of Health Stroke Scale (NIHSS) at presentation was 12.5 (15.8), and 44.2% (87/197) presented with large vessel occlusion (LVO). Approximately 51.3% (98/191) of the patients had poor outcomes with an observed mortality rate of 39.1% (81/207). Age >60 years (aOR: 5.11, 95% CI 2.08 to 12.56, p<0.001), diabetes mellitus (aOR: 2.66, 95% CI 1.16 to 6.09, p=0.021), higher NIHSS at admission (aOR: 1.08, 95% CI 1.02 to 1.14, p=0.006), LVO (aOR: 2.45, 95% CI 1.04 to 5.78, p=0.042), and higher NLR level (aOR: 1.06, 95% CI 1.01 to 1.11, p=0.028) were significantly associated with poor functional outcome.There is relationship between COVID-19-associated AIS and severe disability or death. We identified several factors which predict worse outcomes, and these outcomes were more frequent compared to global averages. We found that elevated neutrophil-to-lymphocyte ratio, rather than D-Dimer, predicted both morbidity and mortality.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
勤劳的老九应助轩辕唯雪采纳,获得10
1秒前
水晶李完成签到 ,获得积分10
4秒前
Bismarck发布了新的文献求助10
10秒前
13秒前
smottom应助轩辕唯雪采纳,获得20
17秒前
晨许沫光发布了新的文献求助10
18秒前
所所应助玄学小生采纳,获得10
20秒前
研友_Ljqal8完成签到,获得积分10
32秒前
JACK完成签到,获得积分10
32秒前
清修完成签到,获得积分10
33秒前
健忘的晓小完成签到 ,获得积分10
33秒前
35秒前
犹豫野狼完成签到 ,获得积分10
36秒前
36秒前
传奇3应助U9A采纳,获得10
42秒前
晨许沫光完成签到 ,获得积分10
45秒前
柒八染完成签到 ,获得积分10
48秒前
49秒前
Bryan应助疯狂的向日葵采纳,获得10
49秒前
酷酷的涵蕾完成签到 ,获得积分10
52秒前
56秒前
朱比特完成签到,获得积分10
57秒前
晟sheng完成签到 ,获得积分10
1分钟前
苹果摇伽完成签到,获得积分10
1分钟前
弄香完成签到,获得积分10
1分钟前
Moonchild完成签到 ,获得积分10
1分钟前
坦率雪枫完成签到 ,获得积分10
1分钟前
Bismarck完成签到,获得积分10
1分钟前
现实的大白完成签到 ,获得积分10
1分钟前
1分钟前
唐唐完成签到 ,获得积分10
1分钟前
1分钟前
Leo完成签到 ,获得积分10
1分钟前
阔达的棒棒糖完成签到,获得积分10
1分钟前
懵懂的怜南完成签到,获得积分10
1分钟前
1分钟前
myth完成签到,获得积分10
1分钟前
鳗鱼白竹完成签到,获得积分10
1分钟前
哇塞完成签到 ,获得积分10
1分钟前
1分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968559
求助须知:如何正确求助?哪些是违规求助? 3513358
关于积分的说明 11167340
捐赠科研通 3248714
什么是DOI,文献DOI怎么找? 1794453
邀请新用户注册赠送积分活动 875065
科研通“疑难数据库(出版商)”最低求助积分说明 804664