Screening Differential CircRNAs Expression Profiles Reveals the Regulatory Role of the has_circTPT1_003–has-miR-218-5p–CCNE2/SMC4 Signaling Axis in Bladder Carcinoma Progression

生物 小桶 小RNA 环状RNA 膀胱癌 基因 计算生物学 癌症研究 癌症 下调和上调 基因表达 折叠变化 分子生物学 基因本体论 遗传学
作者
Jie Wang,Jichun Shao,Linhong Yuan,W.P. Daniel Su,Huiyue Dong,Ping Wang,Zhijie Lin,Jing Feng,Dong Wang,Zhao Hu,Jianming Tan
出处
期刊:DNA and Cell Biology [Mary Ann Liebert, Inc.]
卷期号:41 (2): 128-141 被引量:2
标识
DOI:10.1089/dna.2021.0240
摘要

Circular RNAs (circRNAs) are a class of noncoding RNAs closely related to the development and progression of various human cancers. However, it is unclear whether circRNAs play an important role in the development of bladder cancer. We utilized human circRNA array V2 microarrays to screen circRNA expression profiles in bladder cancer tissues. Bioinformatic tools including circBank, dbDEMC 2.0, miRCancer, TarBase v7.0, miRtarbase, TCGA-BLCA, Cytoscape-MCODE, String, ENCORI, and Venny 2.1 were then employed to construct the circRNA-miRNA-mRNA regulatory networks. In total, 105 upregulated circRNAs and 167 downregulated circRNAs (fold change >2 and p < 0.001) were filtered out. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of filtered dysregulated circRNAs disclosed that the circRNAs regulatory network was closely related with mRNA processing and cell cycle, etc. Further excavation analysis showed that seven differentially overexpressed circRNAs including hsa_circ_0000133, hsa_circ_0023610, hsa_circ_0005615, hsa_circ_0030162, hsa_circ_0077007, hsa_circ_0001140, and hsa_circ_0107031 were associated with bladder cancer invasiveness, and the cell cycle signal axis. has_circTPT1_003-has-miR-218-5p-CCNE2/SMC4 was finally clarified as a possible mechanism for bladder cancer progression. Based on results derived from multiple approaches, we identified that has_circTPT1_003-has-miR-218-5p-CCNE2/SMC4 signal axis may be involved in the invasion process of bladder cancer.
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