生物
性信息素
群体感应
细菌
信息素
受体
信号转导
细胞生物学
第二信使系统
遗传学
生物化学
生物膜
作者
Matthew B. Neiditch,Glenn C. Capodagli,Gerd Prehna,Michael J. Federle
出处
期刊:Annual Review of Genetics
[Annual Reviews]
日期:2017-11-27
卷期号:51 (1): 311-333
被引量:123
标识
DOI:10.1146/annurev-genet-120116-023507
摘要
Bacteria use diffusible chemical messengers, termed pheromones, to coordinate gene expression and behavior among cells in a community by a process known as quorum sensing. Pheromones of many gram-positive bacteria, such as Bacillus and Streptococcus, are small, linear peptides secreted from cells and subsequently detected by sensory receptors such as those belonging to the large family of RRNPP proteins. These proteins are cytoplasmic pheromone receptors sharing a structurally similar pheromone-binding domain that functions allosterically to regulate receptor activity. X-ray crystal structures of prototypical RRNPP members have provided atomic-level insights into their mechanism and regulation by pheromones. This review provides an overview of RRNPP prototype signaling; describes the structure-function of this protein family, which is spread widely among gram-positive bacteria; and suggests approaches to target RRNPP systems in order to manipulate beneficial and harmful bacterial behaviors.
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