乙烯醇
自愈水凝胶
高分子化学
单体
盐酸环丙沙星
核化学
肿胀 的
傅里叶变换红外光谱
差示扫描量热法
盐酸盐
共聚物
化学
聚合
材料科学
氯化铵
聚合物
化学工程
有机化学
复合材料
工程类
物理
生物化学
抗生素
环丙沙星
热力学
作者
Siva Sankar Sana,B. Vijaya Kumar Naidu
标识
DOI:10.1049/iet-nbt.2016.0079
摘要
Herein, the authors developed a new and potential semi-interpenetrating polymer network (semi-IPN) hydrogels of poly vinyl alcohol (PVA), acryl amide and diallyldimethyl ammonium chloride employing chemical cross-linker N, N'-methylene bisacrylamide (NNMBA) and ammonium persulphate as an initiator by radical polymerisation. To analyse the copolymer formation between two monomers and IPN cross-linking reaction, the resulting hydrogel was characterised by Fourier transform infrared spectroscopy and the surface morphology was analysed using scanning electron microscopy. Differential scanning calorimetry and X-ray diffraction studies were also carried out for investigating drug loading and distribution and swelling experiments were carried out for the uptake of water. In vitro release of ciprofloxacin hydrochloride from hydrogel was performed at intestinal conditions. The amount of PVA, NNMBA and total monomer concentration was found to strongly control the drug release behaviour from the hydrogels.
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