杂合子丢失
生物
PTEN公司
拷贝数变化
癌症研究
基因剂量
恶性肿瘤
乳腺
癌症
病理
染色体不稳定性
乳腺癌
基因
遗传学
医学
染色体
基因组
等位基因
基因表达
PI3K/AKT/mTOR通路
信号转导
作者
Kaja Sverdrup Borge,Silje Nord,Peter Van Loo,Ole Christian Lingjærde,Gjermund Gunnes,Grethe I.G. Alnæs,Hiroko Kato Solvang,Torben Lüders,Vessela N. Kristensen,Anne‐Lise Børresen‐Dale,Frode Lingaas
出处
期刊:PLOS ONE
[Public Library of Science]
日期:2015-05-08
卷期号:10 (5): e0126371-e0126371
被引量:31
标识
DOI:10.1371/journal.pone.0126371
摘要
Copy number aberrations frequently occur during the development of many cancers. Such events affect dosage of involved genes and may cause further genomic instability and progression of cancer. In this survey, canine SNP microarrays were used to study 117 canine mammary tumours from 69 dogs.We found a high occurrence of copy number aberrations in canine mammary tumours, losses being more frequent than gains. Increased frequency of aberrations and loss of heterozygosity were positively correlated with increased malignancy in terms of histopathological diagnosis. One of the most highly recurrently amplified regions harbored the MYC gene. PTEN was located to a frequently lost region and also homozygously deleted in five tumours. Thus, deregulation of these genes due to copy number aberrations appears to be an important event in canine mammary tumour development. Other potential contributors to canine mammary tumour pathogenesis are COL9A3, INPP5A, CYP2E1 and RB1. The present study also shows that a more detailed analysis of chromosomal aberrations associated with histopathological parameters may aid in identifying specific genes associated with canine mammary tumour progression.The high frequency of copy number aberrations is a prominent feature of canine mammary tumours as seen in other canine and human cancers. Our findings share several features with corresponding studies in human breast tumours and strengthen the dog as a suitable model organism for this disease.
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