Quercetin and naringenin; effects on ulcer formation and gastric secretion in rats

Abstract The antiulcerogenic effect of two flavonoids, quercetin and naringenin, in acute gastric ulcer (cold‐restraint and pylorus‐ligated) has been investigated. In both models quercetin and naringenin presented a significant decrease in ulcer index with respect to the control group. Nevertheless, in the Shay‐ligated method no decrease in either volume, acidity or pepsin were observed, however, a significant difference was found in histamine secretion values.