Occupational asthma in an electronics factory: a case control study to evaluate aetiological factors

医学 哮喘 职业性哮喘 喘息 过敏性 早晨 病因学 过敏 儿科 内科学 免疫学
作者
Sherwood Burge,W H Perks,I M O'Brien,Alison Burge,R Hawkins,Daniel Brown,M Green
出处
期刊:Thorax [BMJ]
卷期号:34 (3): 300-307 被引量:59
标识
DOI:10.1136/thx.34.3.300
摘要

This is the final part of a study carried out to investigate occupational asthma due to sensitivity to colophony fumes (a component of soldering flux) in an electronics factory. Fifty-eight workers with occupational asthma employed on the main shop floor were investigated. In them the interval between first exposure and sensitisation varied widely with a group becoming sensitive within one to two years of first exposure, and another group whose sensitisation was delayed for three to 23 years. Once sensitised the interval between arriving at work and the onset of daily symptoms seemed to be bimodally distributed, resembling the immediate and late asthmatic symptoms seen on provocation testing. Twenty-three out of 58 had no definite daily deterioration at work but improved at the weekends. Wheeze and breathlessness occurred in the evenings at home in most, and one-third were woken by breathlessness at least on some nights. These 58 cases were compared with 48 controls without occupational asthma who had worked on the same shop floor for at least four years. Mean levels of FEV1 were significantly worse in the cases before exposure on Monday morning. The cases also had more than twice as much sickness absence as controls. FEV1 fell by more than 10% over a working shift in 33% of cases and 5% of controls. Atopy (a positive skin prick test to one or more common allergens) and a past history of allergic disease were weakly but significantly associated with being a case. The effects of smoking and a family history of allergic disease were trivial. Prick testing with an antigen derived from the colophony in the solder flux was completely negative, but cases and controls had significantly raised levels of total IgM compared with blood bank controls, perhaps suggesting some previously unrecognised immunological process.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Orange应助牟云光月采纳,获得10
刚刚
1秒前
有思想完成签到,获得积分10
1秒前
郭文琦完成签到 ,获得积分10
4秒前
肖保定发布了新的文献求助30
4秒前
小陈要努力完成签到,获得积分20
6秒前
7秒前
奇异喵发布了新的文献求助50
8秒前
9秒前
9秒前
侯博文完成签到,获得积分10
9秒前
KK完成签到,获得积分20
12秒前
13秒前
13秒前
小李完成签到,获得积分10
14秒前
15秒前
KK发布了新的文献求助10
15秒前
huiwanfeifei完成签到,获得积分10
17秒前
ZLXLXX完成签到,获得积分10
17秒前
风趣烧鹅完成签到,获得积分10
18秒前
小李发布了新的文献求助10
18秒前
19秒前
华仔应助风趣的老太采纳,获得10
20秒前
哈哈哈完成签到,获得积分10
23秒前
挽风完成签到,获得积分10
24秒前
木头杨完成签到,获得积分10
25秒前
加菲丰丰举报求助违规成功
25秒前
于芋菊举报求助违规成功
25秒前
杀出个黎明举报求助违规成功
25秒前
25秒前
zy发布了新的文献求助10
25秒前
陈晶完成签到,获得积分10
25秒前
meini完成签到 ,获得积分10
28秒前
30秒前
吴大师已经玩明白了完成签到,获得积分10
30秒前
情怀应助木头杨采纳,获得10
31秒前
31秒前
32秒前
zy完成签到,获得积分10
33秒前
bibi发布了新的文献求助10
34秒前
高分求助中
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger Heßler, Claudia, Rud 1000
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 1000
Natural History of Mantodea 螳螂的自然史 1000
A Photographic Guide to Mantis of China 常见螳螂野外识别手册 800
Barge Mooring (Oilfield Seamanship Series Volume 6) 600
ANSYS Workbench基础教程与实例详解 500
Spatial Political Economy: Uneven Development and the Production of Nature in Chile 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 内科学 物理 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 免疫学 细胞生物学 量子力学
热门帖子
关注 科研通微信公众号,转发送积分 3325436
求助须知:如何正确求助?哪些是违规求助? 2956111
关于积分的说明 8579280
捐赠科研通 2634104
什么是DOI,文献DOI怎么找? 1441705
科研通“疑难数据库(出版商)”最低求助积分说明 667930
邀请新用户注册赠送积分活动 654703