Prostate Volume Changes Over Time: Results From the Baltimore Longitudinal Study of Aging

No AccessJournal of UrologyAdult Urology1 Oct 2009Prostate Volume Changes Over Time: Results From the Baltimore Longitudinal Study of Aging Stacy Loeb, Anna Kettermann, H. Ballentine Carter, Luigi Ferrucci, E. Jeffrey Metter, and Patrick C. Walsh Stacy LoebStacy Loeb James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland , Anna KettermannAnna Kettermann James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland , H. Ballentine CarterH. Ballentine Carter James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland , Luigi FerrucciLuigi Ferrucci National Institute on Aging, National Institutes of Health Clinical Research Branch, Baltimore, Maryland , E. Jeffrey MetterE. Jeffrey Metter National Institute on Aging, National Institutes of Health Clinical Research Branch, Baltimore, Maryland , and Patrick C. WalshPatrick C. Walsh James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland View All Author Informationhttps://doi.org/10.1016/j.juro.2009.06.047AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: According to a 1944 publication by Swyer benign prostatic hyperplasia develops in some men after age 45 with further prostatic growth whereas in other men prostate size remains stable or decreases with advancing age. Although there is an abundance of literature describing prostatic enlargement in association with benign prostatic hyperplasia, less is known about the phenomenon of prostate atrophy. Materials and Methods: In the Baltimore Longitudinal Study of Aging serial pelvic magnetic resonance imaging was performed in men without prostate cancer beginning in 1993. From this population we retrospectively identified 278 men with 2 or more magnetic resonance imaging determined prostate volume measurements to examine differential growth rates in a cohort of community men over time. Results: Median age was 58 years and median prostate size was 28 cc at study entry. At a median followup of 4.3 years prostate size increased in 61.9% and remained stable or decreased in 38.1% of men. The median rate of volume change was 0.6 cc per year (range −9.9 to 62.1), corresponding to a median growth rate of 2.5% per year (range −29.2 to 176.4%). During followup 64.6% of men with an initial prostate size less than 40 cc had prostate growth compared to only 50.9% of men with an initial prostate size of 40 cc or greater. Conclusions: These results suggest that changes in prostate size are highly variable among aging men. Although benign prostatic hyperplasia is common, a considerable proportion of aging men have a stable or decreasing prostate size. 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Crossref, Medline, Google Scholar © 2009 by American Urological AssociationFiguresReferencesRelatedDetailsCited bySharkey C, Long X, Wang Z, Al-Faouri R, Gershman B, Tsai L and Olumi A (2021) Zonal Growth Pattern of the Prostate Is Affected by Age and Body Mass IndexJournal of Urology, VOL. 207, NO. 4, (876-884), Online publication date: 1-Apr-2022.Bechis S, Otsetov A, Ge R and Olumi A (2014) Personalized Medicine for the Management of Benign Prostatic HyperplasiaJournal of Urology, VOL. 192, NO. 1, (16-23), Online publication date: 1-Jul-2014. Volume 182Issue 4October 2009Page: 1458-1462 Advertisement Copyright & Permissions© 2009 by American Urological AssociationKeywordsatrophyprostatic hyperplasiaprostatelongitudinal studiesorgan sizeMetricsAuthor Information Stacy Loeb James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author Anna Kettermann James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author H. Ballentine Carter James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author Luigi Ferrucci National Institute on Aging, National Institutes of Health Clinical Research Branch, Baltimore, Maryland More articles by this author E. Jeffrey Metter National Institute on Aging, National Institutes of Health Clinical Research Branch, Baltimore, Maryland More articles by this author Patrick C. Walsh James Buchanan Brady Urological Institute, Johns Hopkins Medical Institutions, Baltimore, Maryland More articles by this author Expand All Advertisement PDF downloadLoading ...