医学
促炎细胞因子
炎症
HMGB1
鼻窦炎
鼻腔灌洗
胃肠病学
细胞因子
内科学
免疫学
肿瘤坏死因子α
病理
过敏
作者
Hyun Jin Min,Su Jin Kim,Tae Hoon Kim,Hyo Jin Chung,Joo‐Heon Yoon,Chang‐Hoon Kim
摘要
Objective High mobility group box 1 (HMGB1) protein is a chromatin protein that functions as a proinflammatory cytokine when secreted in response to inflammatory stimuli. The purpose of this study was to determine the relationship between the HMGB1 level in nasal secretions and the severity of inflammation in chronic rhinosinusitis. Study Design This was a cross‐sectional study. Methods Nasal secretions were obtained by irrigation of the affected sinonasal cavities with normal saline. Total 63 nasal lavage fluid samples were collected from 38 patients with chronic rhinosinusitis who underwent endoscopic sinus surgery. Levels of HMGB1 and tumor necrosis factor alpha, interleukin (IL)−1β, and IL‐8 were determined by enzyme‐linked immunoassay. Severity of inflammation was assessed by the Lund‐Mackay scoring system, which is based on preoperative computed tomography scans. Concurrent medical disorders, presence of nasal polyps, septal deviation, and allergic rhinitis were also investigated. Results The level of HMGB1 in nasal lavage fluid was positively correlated with the Lund‐Mackay score. The score was the only factor associated with HMGB1 by univariate and multivariate analysis. Other cytokines, with the exception of IL‐8, were not correlated with the Lund‐Mackay score. Conclusion Our results showed that HMGB1 is secreted into the extracellular area space in the upper airway, and HMGB1 levels in nasal lavage fluid correlate with severity of inflammation, as assessed by the Lund‐Mackay staging system for chronic rhinosinusitis. These results provide evidence for HMGB1 as an inflammatory mediator associated with the severity of chronic rhinosinusitis. Level of Evidence N/A. Laryngoscope , 125:E225–E230, 2015
科研通智能强力驱动
Strongly Powered by AbleSci AI