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Level of secreted HMGB1 correlates with severity of inflammation in chronic rhinosinusitis

医学 促炎细胞因子 炎症 HMGB1 鼻窦炎 鼻腔灌洗 胃肠病学 细胞因子 内科学 免疫学 肿瘤坏死因子α 病理 过敏
作者
Hyun Jin Min,Su Jin Kim,Tae Hoon Kim,Hyo Jin Chung,Joo‐Heon Yoon,Chang‐Hoon Kim
出处
期刊:Laryngoscope [Wiley]
卷期号:125 (7) 被引量:29
标识
DOI:10.1002/lary.25172
摘要

Objective High mobility group box 1 (HMGB1) protein is a chromatin protein that functions as a proinflammatory cytokine when secreted in response to inflammatory stimuli. The purpose of this study was to determine the relationship between the HMGB1 level in nasal secretions and the severity of inflammation in chronic rhinosinusitis. Study Design This was a cross‐sectional study. Methods Nasal secretions were obtained by irrigation of the affected sinonasal cavities with normal saline. Total 63 nasal lavage fluid samples were collected from 38 patients with chronic rhinosinusitis who underwent endoscopic sinus surgery. Levels of HMGB1 and tumor necrosis factor alpha, interleukin (IL)−1β, and IL‐8 were determined by enzyme‐linked immunoassay. Severity of inflammation was assessed by the Lund‐Mackay scoring system, which is based on preoperative computed tomography scans. Concurrent medical disorders, presence of nasal polyps, septal deviation, and allergic rhinitis were also investigated. Results The level of HMGB1 in nasal lavage fluid was positively correlated with the Lund‐Mackay score. The score was the only factor associated with HMGB1 by univariate and multivariate analysis. Other cytokines, with the exception of IL‐8, were not correlated with the Lund‐Mackay score. Conclusion Our results showed that HMGB1 is secreted into the extracellular area space in the upper airway, and HMGB1 levels in nasal lavage fluid correlate with severity of inflammation, as assessed by the Lund‐Mackay staging system for chronic rhinosinusitis. These results provide evidence for HMGB1 as an inflammatory mediator associated with the severity of chronic rhinosinusitis. Level of Evidence N/A. Laryngoscope , 125:E225–E230, 2015
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