化学
ED50公司
卡拉胶
消炎药
立体化学
阿司匹林
IC50型
恶二唑
药理学
对接(动物)
水肿
环氧化酶-2抑制剂
结构-活动关系
体外
环氧合酶
生物化学
酶
有机化学
医学
心理学
护理部
精神科
作者
Sumit Bansal,Manju Bala,Sharad Kumar Suthar,Shivani Choudhary,Shoumyo Bhattacharya,Varun Bhardwaj,Sumit Singla,Alex Joseph
标识
DOI:10.1016/j.ejmech.2014.04.045
摘要
A novel series of 2-phenyl-5-(1,3-diphenyl-1H-pyrazol-4-yl)-1,3,4-oxadiazoles were designed and synthesized for selective COX-2 inhibition with potent anti-inflammatory activity. Among the compounds tested, 9g (2-(3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl)-5-phenyl-1,3,4-oxadiazole) was found to be the most potent inhibitor of COX-2 with IC50 of 0.31 μM showing promising degree of anti-inflammatory activity in the carrageenan-induced rat paw edema model with ED50 of 74.3 mg/kg. The lead compound 9g further showed suppression of acetic acid-induced writhes comparable to that of aspirin and gastro-sparing profile superior to the aspirin. Molecular docking analysis displayed higher binding affinity of ligands towards COX-2 than COX-1.
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